Cardio Pharm

Front 1

statins: mech, action, ae

Back 1

inhibit mevalonate

drop LDL alot, rise HDL ,drop TG

can cause myositis and increased LFT's

Front 2

niacin: mech, action, ae

Back 2

drop ldl, increase hdl, drop tg

inhibits lipolysis in adipose tissue
reduces hepatic vldl secretion into circulation

causes red, flushed face (which decreases with aspirin or long term use)

Front 3

bile acid resins: mech, action, ae

Back 3

drop ldl, slight rise in both hdl and tg

prevent intestinal reabsorbtion of bile acids, liver must use cholesterol to make more

tastes bad, GI discomfort, and decreases fat soluble vitamin absorbtion

Front 4

ezetimibe: mech, action, ae

Back 4

prevents cholesterol reabsorbtion a small intesting brush border

drop LDL (no real effect on HDL or TG)

rarely can cause increased LFT's

Front 5

Fibrates: mech , action, ae

Back 5

drop ldl, rise hdl, big drop in TGs

upregulate LPL causing increased TG clearance

can cause myositis and increased lft's

Front 6

regimen for high LDL

Back 6

statins then ezetimibe

Front 7

regimen for high TG

Back 7

fibrates then niacin

Front 8

regimen for low HDL

Back 8

niacin

Front 9

antidote to digoxin toxicity

Back 9

normalize K+
lidocaine
cardiac pacer
anti-Dig Fab fragments
Mg2+

Front 10

Action of Class I?

Back 10

the decrease Na channel (phase 0) of cardiac action potential

class IA prolongs repolarization (phase 3, Ik)

class IB shortens reporalization (phase 3, Ik)

class IC doesn't effect phase 3

Front 11

Class II action

Back 11

decrease cAMP and Ca current, decreases phase 4 (If) of pacemaker node (esp AV node)

Front 12

metoprolol ae

Back 12

dyslipidemia

Front 13

Amiodarone: mech, ae

Back 13

it does lots of stuff, class IA and class III

can cause pulmonary fibrosis, heptotoxicity, and thyroid dysfunction (hypo or hyper)

"check PFTs, LFTS, and TFTs"

Front 14

Class IV: mech, use

Back 14

decrease Ica of (phase 0) of AV node

used mostly for atrial tach