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11 Cards in this Set
- Front
- Back
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apoproteins/apolipoproteins
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solubilize insoluble lipid components, allow transport in the plasma
servea as binding ligands; allows lipids to be internalized to the cell from circulation activate or inhibit enzymes facilitate utilization of TG and Cholestero and FA to supply energy |
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chylomicrons
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largest lipoproteins;
converted to smaller remnants in the body dietary particles primarily TG; hydrolyzed by Lpl Normal metab of chylo: source of HDL |
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VLDL
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Made by the liver
source of energy and FA its a particle synthesized for energy that becomes atherogenic when metabolized |
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HDL
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lipoportein that accepts free cholesterol
looks like hockey puck with central cleft---> becomes spherical mature HDL is taken out of circulation by liver: revers cholesterol transport |
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primodial prevention of CHD
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prevention of the development of risk factor: prevent obesity HTN smoking
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primary prevention
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prevention of disease in people w/o manifestations of diseas, but w/risk factores
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Secondary prevention
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prevention of recurrent event in people that have already had atherosclerotic event
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Statins
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HMG-CoA reductase inhibitors
inhibit rate limiting step of choleserol sythesis increase expresssion of LDL receptors that internalize LDL and cholesterol increased removal from circulation ASE: muscle aches and pains if receptor is abnormal, wont really help |
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bile acid binding resins
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taken orally never absorbed
bind bile acids in hepatocyte; turns on bile acid synthesis from cholesterol (lowers intracellular cholesterol and up regs receptor) |
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zetia
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cholesterol absorption inhibitor
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hypertriglyceridemia
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risk factor for the development of pancreatitis
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