Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
Which would kill you...no para or no symp?
|
No para
|
|
|
What ratio of epi to norepi is released by the adrenal medulla?
|
2/3 epi to 1/3 NE
|
|
|
Tyrosine hydroxylase does what?
|
Converts tyrosine to L-Dopa--if you inhibit this then you block dopamine synthesis
|
|
|
How do you terminate Norepi release?
|
Stimulate Postganglionic Alpha 2 receptors causing a negative feedback shutdown of Norepi release
|
|
|
A-methyl tyrosine
|
Inhibits tyrosine hydroxylase
Uses: Pheocromocytoma ASE: Hypotension and sedation |
|
|
What does cocaine do to NE?
|
Blocks its reuptake
|
|
|
Where are alpha 1 receptors found?
|
Vascular smooth muscle cells and pupil dilatory muscles
|
|
|
Where are alpha 2 receptors found?
|
Postganglionic presynaptic receptors that inhibit NE release--also in platelets to cause aggregation
|
|
|
Where are beta 1 receptors found?
|
Heart, fat cells
Action is to activate adenylate cyclase |
|
|
Where are B2 receptors found?
|
Respiratory and vascular smooth muscle
Cause vasodilation |
|
|
Where are the cells with dopamine receptors?
|
D1--smooth muscle, renal blood vessels--cause renal VASODILATION
D2--CNS |
|
|
How is epi made?
|
Dopamine is hydroxylated at the beta carbon to make Norepi and Norepi is methylated in the adrenal glands into epi
|
|
|
What are some drugs affected by chirality?
|
Propanolol and Sotalol
|
|
|
What are the two main enzyme systems that break down sympathetic transmitters?
|
COMT and MAO
|
|
|
Which drugs are susceptible to being broken down by COMT and which are vulnerable to MAO?
|
Catecholamines are broken down by COMT
Vulnerable amino terminal drugs are broken down by MAO |
|
|
What drugs all cause NE release from nerve terminals?
|
Amphetamines
|
