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10 Cards in this Set
- Front
- Back
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microscopic polyangitis
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like Wegener's but lacks granulomas
p-ANCA (perinuclear) - Wegeners is c-ANCA affects small vessels |
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primary pauci-immune crescentic glomerulonephritis
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vasculitis ltd to kidney
pauci-immuni = paucity of antibodies |
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Churg-Strauss syndrome
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granulomatous vasculitis with eosinophilia
- involves lung, heart, skin, kidneys, nerves - often seen in atopic patients - p-ANCA |
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Sturge-Weber disease
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congenital vascular disorder
- affects capillary-sized blood vessels - port-wine stain on face and leptomeningeal angiomatosis (intraceremral AVM) affects small vessels |
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henoch-Schonlein purpura
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MOST COMMON CHILDHOOD SYSTEMIC VASCULITIS
- skin rash (palpable purpura) - arthralgia - intestinal hemorrhage - abdominal pain - melana Follows URIs - multiple lesions of same age small vessels - common triad: skin, joints, GI |
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Buerger's disease
- aka - THROMBOANGIITIS OBLITERANS |
- aka - THROMBOANGIITIS OBLITERANS
- idiopathic segmental, thrombosing vasculitis of small and medium peripheral arteries and veins - seen in heavy smokers sx's - heavy SMOKERS - intermittent claudication - nodular phlebitis - cold sensitivity (Raynaud's phenomenon) - severe pain in affected part - may lead to gangrene smoking cessation affects small and medium vessels |
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Kawasaki disease
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acute, self-ltd disease of INFANTS/KIDS
- acute necrotizing vasculitis of small/medium sized vessels - fever, congested conjunctiva - changes in lips/oral mucosa (STRAWBERRY TONGUE) - lymphadenitis - may develop CORONARY ANEURYSMS small and medium sized vessels |
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polyarteritis nodosa (PAN)
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- necrotizing IMMUNE COMPLEX INFLAMMATION of medium sized muscular arteries
- fever, weight loss, malaise, abdominal pain, melena, ha, myalgia, htn, neurologic dysfunction, cutaneous eruptions - HepB (or C) seropositivity in 30% of pts - multiple aneurysms and constricitons on arteriogram - typically not associated with ANCA Tx: corticosteroids, cyclophosphamide affects medium arteries - typically involves renal and visceral vessels - lesions are different stages |
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Takayasu's arteritis
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"PULSELESS DISEASE"
- granulomatous thickening of aortic arch and/or proximal great vessels - associated with increased ESR - primarily affects ASIAN females <40yrs old FAN MY SKIN ON WEDNESDAY Fever Arthritis Night sweats MYalgia SKIN nodules Ocular disturbances Weak pulses in upper extremities |
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Temporal arteritis (giant cell)
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most common vasculitis that affects medium and large arteries, usually branches of carotid artery
- focal GRANULOMATOUS INFLAMMATION - ELDERLY FEMALES sx's: - unilateral ha - jaw claudication - impaired vision (occlusion of opthalmic artery) increased ESR half of pts have systemic involvement and polymyalgia rheumatica high dose steroids |
