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58 Cards in this Set

  • Front
  • Back
what happens at the PCT
workhorse of nephron thus everything is reabsorbed but H

Na
H20
Bicarbonate
Glucose
AA
Vitamins
K
Ca
Cl
what happens at the descending LOH
Reabsorption of WATER ONLY
what happens at the ascending LOH
Na, Cl, Ca, Mg, some K reabsorption

some K is lost to urine and creates force to drive Ca and Mg reabsorption

no water reabsorption!
what happens in the DCT
Na, Cl, Ca reabsorbed

no water reabsorption unless ADH acts on it
what happens at the CD
Na and water reabsorption

K excretion into liver
where is water not reabsorbed in kidney
Ascending Loop of Henle
DCT unless ADH is there
where is water reabsorbed in kidney
PCT, descending LOH, DCT when ADH there, and CD
COLT Pee
CAI work @ PCT
Osmotics work @ loop
Loop work @ Ascending LOH
Thiazides work @ DCT
Potassium sparing work @ CD
what is unique about CD
K is excreted
what do diuretics do
they cause the opp to happen wherever they work at
what are the diuretics available
CAI
Osmotics
Loop Diuretics
Thiazides
K sparring
acetozolamide (diamox)
CAI
furosemide (lasix)
loop diuretic
ethacrynic acid
loop diuretic
hydrochlorothiazide
thiazide
aldosterone
cause K excretion
spironolactone
k sparing
mannitol
osmotic
where do CAI work
PCT
where do loop diuretics work
Ascending LOH
what drug works on DLOH
none specificly but osmotics work everywhere in nephron
where do thiazides work
DCT
where do K sparing diuretics work
CD
where do osmotics work
everywhere in nephron
acetozolamide (diamox)

MOA
USe
Action
Side effects
MOA: works on PCT and inhibits CA thus bicarbonate not made so Na and bicarbonate are not reabsorbed

actions: excretion of Na and bicarb

use: glaucoma, alkanilize urine, metabolic acidosis, altitude sickness

side effects: metabolic acidosis; sulfa allergies
what should never be in urine
glucose and protein
furosemide (lasix)

MOA
use
action
side effects
MOA: works at ascending LOH and inhibits Na/Cl/K cotransport

actions: Na/K/Cl/Ca/Mg lost in urine

use: edema for CHF, cirrhosis, nephritic syndrome, HTN, hypercalcemia

side effects: ototoxicity, hypokalemia, dehyydration, sulf,nephritis, gout
ethacrynic acid
works like furosemide

but doesnt have sulfa so safe for pts with sulfa allergies
what does furosemide due
decreases BP
hydrochlorothiazide
works on DCT and inhibits the Na/Cl pump causing Na, Cl urine exretion BUT Ca reabsorption!
use of thaizides
HTN
CHF
hypercalciuria
side effects of thiazides
hypokalemia
metabolic acidosis
hyperglycemia
hypernatremia
hyperlipidemia
sulfa allergies
Aldosterone works where
CD
what does aldosterone do
increases reabsorption of Na with H2O following

excretion of K and H
aldosterone causes what
Increase BP & HYPOKALEMIA
Aldosterone doesnt spare what
K
what spares K
K sparing diuretics; anatgonize aldosterone
what is a K sparing diuretic
spiroloactone
where do K sparing work
CD
why do K sparing work at CD
because CD is place where most K is lost in urine
Spiroloactone blocks
aldosterone
use of K sparing
Hyperaldosteronism
K depletion
CHF
side effects of K sparing
hyperkalemia
gynecomastia
antiandrogen effects
what do osmotics like manitol do
increase osmolarity thus increasing urine flow
osmotic use
shock
drug overdose
decrease intracranial pressure and IOP
osmotic side effect
pulmonary edema
dehydration
CHF
diuretics do what to NaCl in urine
increase it
diuretics do what to urine K
increases except for K sparing ones
blood pH is decreased (acidic) w/
CAI
K sparring
blood pH is high (basic) w/
loop diuretics
thiazides
urine Ca is increased w
loop diuretics
urine Ca is decreased w
thiazides
drug that increases urinary excretion of uric acid thus decreasing serum urate levels
probenecid
use of probenecid
gout
probenecid side effects
HA
dizzy
GI
uric acid stones
dermatitis
hematuria
colchicine
used for gout
colchicine MOA
blunts uric acid crystals thus inhibiting them from joining together and making big one
colchicine side effects
diarrhea
BM depression
alopecia