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13 Cards in this Set
- Front
- Back
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Describe the alternative high energy phosphate compound that serves to maintain the ATP pool.
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PHOSPHOCREATINE
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Compare the rate of ATP synthesis between Creatine Kinase and Oxidative Phosphorylation.
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ATP synthesis via Creatine Kinase is 10 times faster than from oxidative phosphorylation
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Describe the function of the Phosphocreatine Shuttle.
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Phosphocreatine Shuttle is designed to maintain the [ATP] relatively constant until the muscle nears exhaustion.ATP from mitochondria is transported to cytososol so it can be used by muscle, phosphocreatine is exchanged into mitochondria to regenerate ADP to ATP
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Describe the Phosphocreatine / ATP energy pool timeline during exercise.
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Phosphocreatine levels are rapidly depleated as they donate their phospate to sustain the ATP stores. When they are depleated the ATP stores drop and the muscle reaches exhaustion.
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Indicate the difference between Creatine and Creatinine.
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Creatinine is a breakdown product of Creatine (among other things). It has lost a H2O and is rid of by the kidneys.
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Identify the dietary and endogenous sources of Creatine.
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Dietary = beef, fish, suppliments
Endogenous = liver |
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List the pros and cons of Creatine Supplementation
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Pros: Strength, Muscle Mass, Speed
Cons: Cramps, Diarrhea, Bloating, Injuries, unknown effects of creatinine |
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What is the function of the Phosphocreatine Shuttle?
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Phosphocreatine Shuttle is designed to maintain the [ATP] relatively constant until the muscle nears exhaustion.
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Describe the Phosphocreatine / ATP Energy Pool timeline?
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Identify the 2 main energy sources of the heart.
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Glucose & Fatty Acids (heart prefers)
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Identify the metabolic pathway stimulated during a myocardial infarct.
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Glycolysis
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Describe the benefits of glycolysis on a hypoxic or ischemic heart.
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Glycolysis supports an hypoxic or ischemic heart. It delays progression of the ischemic contraction & increases chances that functionality will be restored upon reperfusion.
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Use Evidence Based Medicine to evaluate GIK therapy for MI patients.
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The initial trials suggested that GIK infusion might be beneficial in patients with acute coronary syndromes who were not treated with reperfusion. However, the more recent trials (GIPS-I, GIPS-II, and CREATE-ECLA) utilizing current rapid reperfusion therapies have failed to demonstrate any benefit in the administration of GIK with acute coronary syndromes.
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