Cardio Antiarrythmia Drugs

Front 1

Procainamide Mechanism of Action, Indication, ASE

Back 1

Class IA Antiarrythmic, Prolongs QT interval by blocking Na channels (active) and K channels, For atrial or ventricular arrythmias but rarely used, depresses LV function, and can cause drug induced lupus

Front 2

Lidocaine Mechanism of Action, Indication, ASE

Back 2

Class IB antiarrythmic. Blocks inactivated Na channels to DECREASE QT, used for Ventricular arrythmia in emergency (VT, VF). No effect on atria, Can have neurotox at high dose

Front 3

Flecainide Mechanism of Action, Indication, ASE

Back 3

Class IC anti arrythmic. Blocks Na channels, NO effect on QT, atrial and rarely Ventricular arrythmias, depresses LV function. Never use in heart failure patient

Front 4

Quinidine Mechanism of Action, Indication, ASE

Back 4

Class IA antiarrythmic, blocks Na and K channels, to PROLONG QT interval, indicated for atrial and ventricular arrythmias but not used often. Depresses LV function, causes constipation and diarrhea

Front 5

Disopyramide Mechanism of Action, Indication, ASE

Back 5

Class IA antiarrythmic, blocks Na and K channels, to PROLONG QT interval, indicated for atrial and ventricular arrythmias but not used often. Depresses LV function.

Front 6

Tocainide Mechanism of Action, Indication, ASE

Back 6

Class IB antiarrythmic, blocks inactive NA channels to SHORTEN QT interval. Use for emergency ventricular arrythmias, no effect on atrial, causes agranulocytosis

Front 7

Propafenone Mechanism of Action, Indication, ASE

Back 7

Class IC antiarrythmic, blocks Na channels with NO EFFECT on QT interval, used for atrial and rarely ventricular arrythmias, Many side effects, depresses LV function and never use in heart failure

Front 8

Amiodarone Mechanism of Action, Indication, ASE

Back 8

Class III antiarrythmic K channel blocker. PROLONGS QT (most commonly used anti arrythmic today), Used for ventricular and atrial arrythmias, long term ASE at high dose but does not depress LV fxn so GOOD FOR HF patients

ASE: Thyroid, Pulmonary, Liver, Eye

Front 9

Verapamil Mechanism of Action, Indication, ASE

Back 9

Class IV Ca channel blockers, NO EFFECT on QT, more or less like beta blockers to decrease conduction rate and automaticity. USED FOR ATRIAL ARRYTHMIAS and to prevent ventricular arrythmias due too ischemia

Front 10

Diltiazem Mechanism of Action, Indication, ASE

Back 10

Class IV Ca channel blockers, NO EFFECT on QT, more or less like beta blockers to decrease conduction rate and automaticity. USED FOR ATRIAL ARRYTHMIAS and to prevent ventricular arrythmias due too ischemia

Front 11

Sotalol Mechanism of Action, Indication, ASE

Back 11

Class III anti arrythmic, blocks K channels to PROLONG QT. Commonly used for ventricular and atrial arrythmias, Causes TORSADE and BRADYCARDIA

Front 12

Dofetilide Mechanism of Action, Indication, ASE

Back 12

Class III anti arrythmic, blocks K channels to PROLONG QT. Commonly used for ventricular and atrial arrythmias, Causes TORSADE

Front 13

Ibutilide Mechanism of Action, Indication, ASE

Back 13

Class III anti arrythmic, blocks K channels to PROLONG QT. Commonly used for ventricular and atrial arrythmias, Causes TORSADE esp w/ LV dysfunction. USED FOR ACUTE ATRIAL FIBRILLATION

Front 14

Adenosine Mechanism of Action, Indication, ASE

Back 14

Opens IK-Ach-Ado channel used to dramatically slow conduction through AV node, Breaks AVNRT, AVRT arrythmias to allow a diagnosis if in Atrial fibrillation or tachycardia, Can cause bronchospasm and patient will not feel good

Front 15

Propanolol Mechanism of Action, Indication, ASE

Back 15

Non selective B-blocker, blocks B1 receptors (heart contractility), and B2 receptors (sympathetic cholinergic so muscle vessels and lung vessels may expand don't use with asthmatics), Used for SUPRAVENTRICULAR ARRYTHMIA, ASE: bradycardia, heart blocks, precipitates congestive heart failure

Front 16

Timolol Mechanism of Action, Indication, ASE

Back 16

Non selective B-blocker, blocks B1 receptors (heart contractility), and B2 receptors (sympathetic cholinergic so muscle vessels and lung vessels may expand don't use with asthmatics), Used for SUPRAVENTRICULAR ARRYTHMIA, ASE: bradycardia, heart blocks, precipitates congestive heart failure

Front 17

Metoprolol Mechanism of Action, Indication, ASE

Back 17

Class II beta blocker, cardioselective for B1 receptors, used for hypertension, congestive heart failure and arrythmias, Can cause vivid dreams. NO RISK OF BRONCHOSPASM

Front 18

Butoxamine Mechanism of Action, Indication, ASE

Back 18

Selective B2 blocker, no clinical use

Front 19

Carvedilol Mechanism of Action, Indication, ASE

Back 19

combination A1, B1, and B2 blockers that allow hypertension control

Front 20

Torsades de Pointes Treatment

Back 20

Correct hypokalemia, hypomagnesemia, discontinue QT prolonging drugs (Class IA and Class III antiarrythmics)

Front 21

Digoxin MOA, ASE, Indication

Back 21

Cardiac Glycoside, Blocks Na/K Pump to increase contractility by raising Ca++ in, indicated for atrial flutter and atrial fibrillation