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10 Cards in this Set
- Front
- Back
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What was the first clinically viable beta blocker?
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pronanolol
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What happened with first generation beta blockers?
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they were non-selective, antagonized both Beta1 and Beta2 subtypes
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Why would you have a selective beta blocker?
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so that you can avoid bronchoconstrictive and vasoconstrictive effects of Beta2 blockade
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What's up with second generation beta blockers?
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subtype selective, more potent at antagonizing beta1 than beta2
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What's up with third generation beta blockers?
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selective with additional cardiovascular actions, also alpha1 receptor antagonists so that they are more potent anti-hypertensive agents, successful heart failure drugs
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What do intrinsic sympathomimetic effect drugs do?
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partial agonists, counteract an increase in adrenergic stimulation, doesn't affect resting heart rate
preserves BP |
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Why wouldn't you give intrinsic sympathomimetic effect drugs?
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not as good at treating myocardial ischemia or in improving post-MI survival
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What are the other effects of beta-blockers?
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anesthetic, membrane stabilizer, produce NO, activate beta2 receptors, block Ca entry, open K channels, antioxidant activity
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How often do you have to give a newer beta-blocker?
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once or twice daily
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How often do you give propranalol?
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four times daily
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