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26 Cards in this Set
- Front
- Back
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List all 7 statins including generic and brand names.
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atorvastatin (Lipitor), simvastatin (Zocor), rosuvastatin (Crestor), pravastatin (Pravachol), fluvastatin (Lescol XL), lovastatin (Mevacor), amlodipine/atorvastatin (Caduet)
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What is the mechanism of a statin?
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Inhibits HMG-CoA reductase
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What is the adverse effect of statin?
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myositis
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List the generic and brand names for all the fibrate drugs.
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gemfibrozil (Lopid), fenofibrate (Tricor, Antara, Lofibra)
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What is the mechanism of a fibrate?
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Enhances the synthesis of lipoprotein lipase, an enzyme responsible for VLDL catabolism,
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What are the indications for fibrate?
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Reduce elevated triglyceride levels and increase HDL cholesterol
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What is one adverse effect of a fibrate?
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GI complaints
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Give the 3 brand and generic names of Nicotinic Acid (Vitamin B3) drugs?
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niacin (Niaspan), niacin & lovastatin (Advicor), niacin and simvastatin (Simcor)
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What is the mechanism of Nicotinic Acid (Vitamin B3) drugs?
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Lipid metabolism thereby reducing LDL and triglycerides levels
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What are the indications for Nicotinic Acid (Vitamin B3) drugs?
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The best agent for increasing HDL
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What are the side effect of Nicotinic Acid (Vitamin B3)?
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GI complaints (gas, nausea, bloating), flushing
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What are 2 examples of drugs (Brand and generic name) from the 2-Azetidinone Cholesterol Lowering Agent?
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ezetimibe (Zetia) and ezetimibe & simvastatin (Vytorin)
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What is the mechanism of 2-Azetidinone Cholesterol Lowering Agent?
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Inhibits cholesterol absorption in the small intestine
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What is an adverse effect for 2-Azetidinone Cholesterol Lowering Agent?
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GI complaints
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What is an example of a bile acid sequestrant drug (Brand and generic name)?
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Colesevelam (Welchol)
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What is the mechanism of a Bile Acid Sequestrant?
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Blocking the reabsorption of bile acid in the intestine
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What are the adverse effects of a bile acid sequestrant?
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constipation, dyspepsia, elevated triglycerides
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What is an example of Omega-3 Fatty Acids Cholesterol Lowering Agent (Brand and generic name)?
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Omega-3-Acid Ethyl Esters (Lovaza)
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What is the indication for an Omega-3 Fatty Acids Cholesterol Lowering Agent?
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Treatment of hypertriglyceridemia (≥500 mg/dL)
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What are the adverse effects for Omega-3 Fatty Acids Cholesterol Lowering Agent?
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belching, upset stomach
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What are the examples of Long-Acting Nitrate drugs (brand and generic names)?
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Isosorbide mononitrate (Imdur, Ismo, Monoket), isosorbide dinitrate (Isordil, Dilatrate SR), nitroglycerin ointment (Nitro-Bid 2%), nitroglycerin transdermal (Minitran, Nitro-Dur)
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What is the indication for long-acting nitrate?
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prevention of angina
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What are the adverse effects of long acting nitrate?
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postural hypotension, headache, dizziness, syncope, application site irritation (patch, ointment)
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What are examples of short acting nitrate?
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sublingual nitroglycerin (Nitrostat, Nitroquick), nitroglycerin translingual spray (Nitrolingual)
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What is the indication for short acting nitrate?
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treatment of acute angina
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What are the adverse effects for short acting nitrate?
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postural hypotension, headache, dizziness, syncope, burning or tingling oral sensation
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