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26 Cards in this Set
- Front
- Back
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Felodipinum |
A) 1,4-dihydropyridinecalcium channel blocker
B) inhibits influx of Ca into smooth muscle, activate MLCK →prevents vasoconstriction →vasodilation
C) Hypertension
5 - 10 mg |
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Lacidipinum |
A) 1,4-dihydropyridine calcium channel blocker
B) inhibits influx of Ca into smooth muscle, activate MLCK →prevents vasoconstriction → vasodilation
C) Hypertension |
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Metoprololi tartras i/v, fast and short acting |
A) β-adrenoceptor antagonist B) cardio selective blocksβ1 C) Hypertension, CHD,arrythmias Sol.in amp. 0.1mg/ml |
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Bisoprololum |
A) β-adrenoceptor antagonist B) highly cardio selectiveblocks β1 C) Arrythmias, CHD,heart failure/chronic heart disease,hypertension Tab. 5mg, 10mg |
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Doxazosinum |
A) reversible α-adrenoceptor antagonist
B) Selective blocks α1 - vasodilation
C)Hypertension, BPH |
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Moxonidium |
A) α-adrenoceptor antagonist
B) works Selectively on imidazoline receptor → inhibit sympathetic activity --> inhibit norepinephrine release → which causes peripheral vasodilation
Side effect: dry cough, Angioedema, hyperkalimia, skin rash
C) Hypertension, drug resistent hypertension |
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Clonidinum |
A) direct adrenoceptor agonist
B) works on α2 adrenoreceptor and imadazoline receptor and block sympatic activity and inhibition of norepinephrine release which causes peripheral vasodilation -> decrease BP
C) decrease blood pressure by vasodilation, Hypertensive Crisis,opioids abstinence |
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Bosentanum |
A) Vasodilator: Endothelin Antagonist
B) Bloks TA/ETB receptor →inhibits endothelin production → vasodilation and decreased BP
C) Pulmonary arterial hypertension |
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Enalaprilum |
A) ACE inhibitor
B) inhibition of angiotensin-convertingenzyme → reduction of angiotensin II levels,reduction of vasoconstriction → vasodilation, suppress bradykinin and aldosterone secretion
C) Hypertension, Heart failure, diabetes
Side effect - Angioedema, dry cough, hyperkalimia Remember never combine ACI + NSAIDS => leads to kidney failure!! Tab. 5mg, 10mg, 20mg |
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Perindoprilum |
A) ACE inhibitor
B) inhibition of angiotensin-converting enzyme → reduction of angiotensin II levels,reduction of vasoconstriction,suppress bradykinin and aldosterone secretion
C) Hypertension, Heart failure, diabetes
Tab. 2mg, 4mg |
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Ramiprilum |
A) ACE inhibitor
B) inhibition of angiotensin-converting enzyme → reduction ofangiotensin II levels,reduction of vasoconstriction, suppress bradykininand aldosterone secretion
C) Hypertension, Heart failure, diabetes,reduces risk of death,MI and stroke
Tab. 1.25mg, 2.5mg, 5mg |
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Candesartanum |
A) Angiotensin antagonist
B) angiotensin receptorblocker → antagonizes AT1 receptors →vasodilation, reduction of aldosterone secretion
C) Chronic heart failure,hypertension, diabetic renal disease, reduces mortality
Tab. 4mg, 8mg, 16mg |
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Valsartanum |
A) Angiotensin antagonist B) angiotensin receptorblocker → antagonizes AT2 effects at AT1receptors → vasodilation, reductionof aldosterone secretion C) Chronic heart failure,hypertension, diabetic renal disease, reduces mortality Tab. 40mg, 80mg, 160mg |
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Hydrochlorothiazidum |
A) Diuretics
B) blocks Na/Cl transporter in renal distal convoluted tubule and results in retention of water→ reduction of blood volume → reduction of BP (also: late dilation of blood vessels)
C) Hypertension, mild heart failure
Tab. 25mg, 100mg |
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Furosemidum |
A) Diuretics
B) blocks Na/K+/2Cl cotransporter in renal loop of Henle, resulting in retention of Na/Cl and water → reduction of blood volume → reduction of BP
C) severe hypertension, heart failure
Tab. 40mg |
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Torasemidum |
A) Diuretics
B) blocks Na/K+/2Cl cotransporter in renal loop of Henle, results in retention of Na/ Cl and water →reduction of blood volume → reduction of BP
C) severe hypertension, heart failure, congestive heart failure induced edema
Tab. 2.5mg, 5mg |
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Natriinitroprussias (Sodium nitroprusside, SNP) |
A) parenteral vasodilator (I.v. - Malignant hypertension)
B) it breaks down chemically to NO whic activate of guanylyl cyclase→ vasodilation→ reduced perisperhal vascular resistance
C) Hypertensive emergencies, severe heart failure |
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Norepinephrinum |
A) direct adrenoceptoragonist
B) activates α1+a2, β1receptors
C) Acute Hypotension(increases peripheral resistance & blood pressure) |
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Dopaminum |
A) direct adrenoceptoragonist
B) activates D1 receptors(also a1 & b1)
C) vasodilation of renal,splanchnic vessels; clinically: improve perfusion to kidney,treat oliguria, shock,cardiac arrest may improve cardiacoutput and stroke vol |
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Phenylephrinum |
A) direct adrenoceptor agonist
B) activates only α1receptors -- used in septic shock
C)hypotension, mydratic, decongestant, increases blood pressure |
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Dexamethasonum |
A) synthetic corticosteroids (systemic)
B) anti-inflammatory or Immune suppressant agent
C) in case of allergic, dermatologic and acute hypotension by constriction of blood vessels |
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Main groups of antihypertensive drugs |
A - ACE inhibitor B - Beta blocker C - Calcium channel blocker D - Diuretics |
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Bad combination for kidneys |
ACE + NSAIDS + hypovolemia |
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Nebivolol |
A) Beta 1 blocker(cardioselective) B) " ÷" ino, chronotropic (reduce oxygen demand) and dromotrophic effect (suppress secretion of renin) Vasodilation stimulated by NO C) Arterial hypertension, CHD, CAD |
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Spironolactone |
A) Mineralcorticoid(aldersterone) B) Blocks aldersterone, inhibiting Na reabsorption in distal tubule. Blocks aldersterone receptor in myocardial blood vessel) 1. Weak diuretic effect 2. Antifibrotic effect 3. Anti - androgen effects C) Heart failure, hypertension, primary aldersteronism, Acne vulgaris, Alopecia(women) |
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Telmisartan |
A) Angiotensin II receptor blocker B) Blocks angiotensin AT 1 receptor, reduce synthesis of aldersterone. Dilate of arteries and reduce preload and afterload. C) Hypertension, Chronic heart failure |
