Card 1

Front 1

Glyceriltrinitratum Nitroglycerine

Back 1

A) Anti-anginal agent, nitrates

B) Donates NOx to endothelium, NO activates MLCK and causes vasodilation in peripheral veins > coronary arteries > arteries ( Reduce preload) and (reduce afterload) - increase O2 supply by dilation large coronary arteries.

C) Coronary Artery Disease, Acute Coronary Syndrome, short-time prophylaxis

Short acting

Side effect ; flushing, headache, postural hypotension

Front 2

Isosorbidi mononitras

Back 2

A) Anti-anginal agent, nitrates

B) Donates NOx to endothelium, NO activates MLCK, causes vasodilation in peripheral veins > coronary arteries > arteries

C) Coronary Artery Disease, Acute Coronary Syndrome, short-time prophylaxis

Long acting

Front 3

Nifedipinum

Back 3

A) Calcium channel Blockers, Dihydrodiripin derivates, 1st gen

B) Vasoselective calcium channel blocker → SA node HR and O2 demand decreases, => vasodilation increases in coronary arteries => BP decreases

Dilation of ischemic zone

C) Hypertensive crisis, CHD, CAD, angina, vasospastic angina

Front 4

Amlodipinum

Back 4

A) Calcium channel Blockers, 2nd gen

B) Vasoselective calcium channel blocker → SA node HR and O2 demand decreases => vasodilation in coronary arteries => decrease Bp

C) Hypertension, CHD,CAD, vasospasticangina

Long acting

Front 5

Diltiazemum

Back 5

A) Calcium channel Blockers , Non dihydropiridine

B) Non Vaso + cardioselective calcium channel blocker,cardio and dilate arteries and decrease HR

C) Hypertension, CHD,CAD

Front 6

Propranololum

Back 6

A) β-adrenoceptorantagonist (Antiarrhythmic agent)

B) blocks β1 & β2 (nonselective),

÷ "ino, chronotrophic"(reduce oxygen demand in myocard), dromotrophic(reduce secretion of renin).

Phase 2 of AP => decrease of calcium influx in cardiomyoctes)

Phase 0 and 4 of AP => decrease influx of calcium in SA and AV node.

decrease HR and decrease oxygen supply and contractility → reductionof HR

C) Hypertension (1stchoice), angina pectoris+ acute MI (CHD),tachy-arrythmias,prophylaxis of migrane,hyperthyroidism (thyreotoxicosis)

Front 7

Metoprololitartras

Back 7

A) β-adrenoceptorantagonist

B) cardioselective blocksβ1,÷ "ino, chronotrophic"(reduce oxygen demand in myocard), dromotrophic(reduce secretion of renin).Phase 2 of AP => decrease of calcium influx in cardiomyoctes)Phase 0 and 4 of AP => decrease influx of calcium in SA and AV node.

C) Hypertension, CHD,arrythmias

Long term use of BAB = > hypertension, arrhythmias attack

Front 8

Ivabradinum

Back 8

A) Anti-arrhythmics

B) Blocks funny channels Sinus Node,reduces heart rate without affecting heart physiology (noadrenergic effect)

C) Isolated Tachycardia

NB; must not be used with verapamil => AV block

Front 9

Acidumacetylsalicylicum (Aspirin)

Back 9

A) NSAID

B) Cyclooxygenase inhibitor (COX1/2) →reduction of production of thromboxans →reduced platelets

C) CAD, after coronary syndrome

Front 10

Clopidogrelum

Back 10

A) Anti-platelet agent

B) Binding to ADP receptors (P2Y12receptos) on platelet surface, thereby inhibiting platelet aggregation

C) CAD, after coronarysyndrome

Front 11

Trimetazidinum

Back 11

A) anti-anginal drug, metabolismmodulator

B) Elevates intracellular ATP levels by inhibition of fatty acid oxidation

C) CAD

Front 12

Ranolazinum

Back 12

A) metabolism modulator, anti-anginal agent

B) Reduce intracellular Na activity ,vasodilation of small coronary vessels, Elevates intracellularATP levels by inhibitionof fatty acid oxidation increases O2/Glucoseuptake, esp. Duringischemia

C) Vasospastic angina

Front 13

Atorvastatinum

Back 13

A) Statins

B) Inhibition of HMG Coenzyme (is involved in production of cholesterol) →increases HDL

A) Total cholesterol down

B) Pleiotropic activity

> Antioxidant

> Endothelium protection

>NOx releasing

> Anti inflammatory

> Plaquestabilizing

C) ACD, CHD,artherosclerosis

Front 14

Fenofibratum

Back 14

A) Fibrates

B) Work like Statins! lowerVLDL → increases HDL

1. Total cholesteroldown

2. Pleiotropic activity

> Antioxidant

> Endotheliumprotection

> NOx releasing

> Antiinflammatory

> Plaquestabilizing

C) ACD, CHD,artherosclerosis

Front 15

Ezetimibum

Back 15

A) Cholesterol inhibitor

B) Inhibitor of fat absorption, blocks sterol transporter inintestinal brush border→ decreases LDL and sterols

C) Elevated LDL, digitalistoxicity, if statins prove ineffective

Front 16

Naftidrofurylum

Back 16

A) Peripheral vasodilator

B) it blocks S2 receptor on platelate and smooth muscle of vessels and Improves blood supply,especially in legs,

C) ,peripheral artery disease, angioplasties in DM

Front 17

Diosminum /HesperidumDetralex (R)

Back 17

A) Veno-protective agent

B) Strengthens venous wall, Hesperidum prevents from clots ,anti-inflammatory

C) Varicose vein,hemorrhoids, before/after venous surgery

Front 18

Pentoxyphyllium

Back 18

A) Vasodilator, antiinflammatory drug

B) Increase blood flow to the affected microcirculation, overall oxygenation in tissue increased, works as Vasodilator with anti platelet action !

C) peripheral artery disease, angioplasties in DM

Front 19

Nicergolinum

Back 19

A) reversible α-adrenoceptor antagonist

B) blocks α1 on vasc. Smooth muscles

C) improves cerebral blood flow

Front 20

MONA => immediate treatment of an M.I.(myocardial infarction)

Back 20

M = morphine( i.v.)

O = oxygen (insufflation)

N = nitroglycerin(sublingual)

A = antioagulant (eg. Aspirin)