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31 Cards in this Set
- Front
- Back
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Gene mutations in a cell help determine whether it will become a tumor, but what area is just as important? |
The neighborhood immediately surrounding the cell |
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Workings of the "neighborhood" |
Cells pack tightly against each other like rows of houses. They are surrounded by proteins called the extra cellular matrix. Blood vessels act like pipes to bring in nutrients. Thriving neighborhoods contain trash build up to prevent pollution. |
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What is the BRCA1 gene and what type of cancer can it cause? |
It is a gene mutation and is associated with the cause of breast cancer. |
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Who had her breasts removed because she carries the BRCA1 gene? |
Angelina Jolie |
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___ of every _____ women with the BRCA1 gene will develop breast cancer |
50-70 of every 100 |
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"Neighbors" or factors that keep a tumor in check |
Extra cellular matrix, myoepithelial cells, tissue macrophages, fibroblasts, normal metabolism, antioxidants |
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Neighbors that are cancer promoting |
Aberrant extracellular matrix, aberrant myoepithelial cells, cancer associated fibroblasts, tumor associated macrophages, blood vessel growth, oxidants |
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Structural differences in women with dense breast tissue than other breast tissue |
Less fat, more connective tissue, less CD36 |
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What did breast cells places in a laboratory setting start producing? |
Proteins that go into milk |
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Once a cancer cell has migrated to a new location does is immediately start the growth of a tumor? |
No, it can lay dormant for years |
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A tumor is like an ____, it's a complete functioning unit. |
Organ |
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How does stress impact the risk of cancer? |
By triggering physical pressures, chemical signals, and changes in blood and oxygen levels. It can produce reactive oxygen specials that bash DNA, proteins, lipids and other cell components. Unchecked these molecules get away and cause damage |
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What do researchers believe about oxygen and blood supply to tumors? |
Tumors need oxygen and other nutrients to grow so cutting off a tumors blood supply will potentially starve it |
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An experimental cancer drug that is not poisonous to the body |
Endostatin |
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An experimental cancer drug that is not poisonous to the body |
Endostatin |
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Who proposed the angiogenesis theory? |
Dr. Judith Folkman |
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An experimental cancer drug that is not poisonous to the body |
Endostatin |
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Who proposed the angiogenesis theory? |
Dr. Judith Folkman |
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What nourishes the tumors growth? |
Blood vessels |
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Tumors that travel to other parts of the body are said to |
Metastasis |
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After two years of study, what was produced by separating proteins found in mice urine? |
Angiostatin |
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After two years of study, what was produced by separating proteins found in mice urine? |
Angiostatin |
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Define cancer |
An uncontrolled growth and spread of abnormal cells |
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Causes of cancer |
Smoking, obesity, a few viruses, chemicals, radiation, hormones, immune conditions, inherited genetic mutations |
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An external agent that enters a normal cell and initiates changes |
Carcinogen |
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Types of carcinoma |
Breast, lung, intestines, skin and mouth |
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Types of carcinoma |
Breast, lung, intestines, skin and mouth |
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Carcinoma |
Most common sites for cancer. Found in tissues that cover body's surface, epithelial tissues, and linings |
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Sarcoma |
More dangerous cancer, hard to treat, forms solid tumors, occurs in the middle layers of tissues |
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Sarcoma |
More dangerous cancer, hard to treat, forms solid tumors, occurs in the middle layers of tissues |
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Lymphoma |
Occurs in the lymphatic system |
