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5 Cards in this Set
- Front
- Back
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Retinoblastoma
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RB1 is a tumor supp gene
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Li-Fraumeni
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Autosomal dominant. p53
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Multiple Endocrine Neoplasia Syndrome, type 2A
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Thyroid carcinoma, caused by RET gene (a proto-oncogene)
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Familial adenomatous polyposis (FAP)
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Autosomal dominant, APC tumor suppressor gene
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Hereditary non-polyposis colorectal cancer
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Extra-colonic cancer also arise much more frequently. AD inheritance. DNA mismatch repair issue (MMR family).
DX - family history, Amsterdam criteria, Microsatellite instability, genetic testing. |
