Cancer Genetics 8/31/05

Front 1

___ are new useless organs

Back 1

tumors (neoplasms)

Front 2

Cancers from epithelium are ______

Back 2

carcinomas

Front 3

cancers from mesenchyme are ______

Back 3

sarcomas

Front 4

tumors grow ____ than surrounding tissue, and they never _____ to grow

Back 4

more rapidly

cease

Front 5

___ are ugly cells, a marker for cancer or precancer

Back 5

anaplasia

Front 6

__ a new useless organ produced by cells bearing mutations

Back 6

neoplasia

Front 7

____ ugly cells in an epithelium without invasion "carcinoma in situ"

Back 7

dysplasia

Front 8

A ____ is well differentiated
few mitotic figures and never metastisizes

Back 8

benign

Front 9

____ arise from stratified squamous epithelium and have keratin, pearls, desmosomes, tonofilaments, single cell apoptosis

Back 9

squamous cell carcinomas

Front 10

___ arise anywhere there are glands esp glands within glands swiss cheese

Back 10

adenocarcinoma

Front 11

Most common male cancers are:

Most common femal cancers are:

Back 11

prostate,lung,colon

breast, lung, colon

Front 12

Deadliest male cancers:

deadliest female cancers:

Back 12

lung, prostate, colon

lung, breast, colon

Front 13

___tumor grown lump like cauliflower

Back 13

exophytic

Front 14

___tumor grows like ulcer

Back 14

endophytic

Front 15

____tumor cells invade organ without changing its shape

Back 15

infiltrating

Front 16

lymphatics are traditional spread route for ______

Back 16

carcinomas

Front 17

blood vessels are trad route spread for ______

Back 17

sarcomas

Front 18

__ means glandular epithelium

Back 18

adeno-

Front 19

__ used for squamous or transitinal epith and benign

Back 19

papillo-

Front 20

malignant and nonglandular epithelium use ______ to name

Back 20

origin of cell basal cell renal cell

Front 21

fibro

Back 21

fibroblasts

Front 22

myxo

Back 22

myxoid tissue

Front 23

chondro

Back 23

cartilage

Front 24

osteo

Back 24

osteoblasts

Front 25

lipo

Back 25

fat

Front 26

chordo

Back 26

notochord remnants

Front 27

leiomyo

Back 27

smooth muscle

Front 28

rhabdomyo

Back 28

striated muscle

Front 29

schwanno/neurilemmo

Back 29

nerve sheath (perineurinium)

Front 30

hemangio

Back 30

blood vessels

Front 31

lymphangio

Back 31

lymphatics

Front 32

glomangio

Back 32

glomus

Front 33

meningio

Back 33

arachnoid granulation

Front 34

lympho

Back 34

lymphocytes

Front 35

totipotential cells

Back 35

terato

Front 36

______ is good stuff, good location, wrong proportions

Back 36

hamartoma

Front 37

chorio

Back 37

placenta

Front 38

pheochromocyto

Back 38

adrenal medulla

Front 39

_____ or _____ is mass of normal tissue in wrong place

Back 39

choristoma , ectopia

Front 40

lymphoma, mesothelioma, myeloma,astrocytoma,carcinoid,glioma,ependymoma,seminoma, hepatoma, melanoma, dysgerminoma, leukemia

Back 40

all are malignant but have benign names

Front 41

what disease?
p arm absent, 45X, horseshoe kidney, lymphedema, cyctic hygroma, systolic murmur

Back 41

Turner's

Front 42

human cell cycle lasts ____
mitosis lasts_____
metaphase lasts _____

Back 42

24 h
1-2 h
1 h

Front 43

___ is when long and short arms euqal in length

Back 43

metacentric

Front 44

____centromere offset making short and long arms (like X chromosome)

Back 44

submetacentric

Front 45

___occurs at centromeres of acrocentric chromosome 2 longs stick together short usually lost

Back 45

Robertsonian translocation

Front 46

__ long arm

__ short arm

Back 46

q

p

Front 47

__ is chemical sometimes used to determine banding patterns on chromosomes

Back 47

trysin/w specific stains

Front 48

___ is pictoral representation of chrmosomes showing banding pattern prodecue by stain

Back 48

idiogram

Front 49

____ pictoral display of chromosome collected from each cell

Back 49

karyotype

Front 50

____ when centromere way at one end, very short arm, usually lose it (13,14,15,22)

Back 50

acrocentric

Front 51

___ when chromosomes segments exchange btw chromosome

Back 51

reciprocal translocation

Front 52

____ when chromosome breaks each side of centromere flips 180 rejoins

Back 52

oericentric inversion

Front 53

__ when 2 breaks occur on single arm rotate 180 rejoin

Back 53

paracentric inversion

Front 54

tetraploid /4N causes miscarriages

Back 54

92

Front 55

triploid (3N) 1 egg 2 sperm

Back 55

69

Front 56

47XX+21, 47XY+21,
hypotonia, simian creases, hyperflexibility, excess skin back nexk, clinodactyly
need at least 4 of these for what disease?

Back 56

Downs

Front 57

95% Downs caused by____

Back 57

nondisjunction chromosome pair 21 in 1st meiotic division in females (47) or 14,21 21,21 translocation or could be mosaics

Front 58

_____ has classic triad: cleft lip/palate, polydacyly, eye abnormalities

Back 58

Trisomy 13

Front 59

______ has short sternum, hammer toe, seizure, overlapping digits, heart defect

Back 59

Trisomy 18