Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/24

Click to flip

24 Cards in this Set

  • Front
  • Back
SIS
Proto-oncogene that function in growth factor synthesis; overexpression mutation
Cancers associated with SIS mutation
osteogenic sarcoma or astrocytoma
HER(ERB-B2)
Proto-oncogene that functions in receptor synthesis; amplification mutation
HER/ERB-B2 mutation causes what cancer
Breat carcinoma
RET
Proto-oncogene that functions in receptor synthesis; point mutation
Cancer associated with RET mutation
MEN IIa/IIb
RAS
Proto-oncogene that functions in GTP-signal transduction; point mutation
Cancers associated with RAS mutation
Leukemia, lung, colon, pancreatic carcinomas
ABL
Proto-oncogene that functions in nonreceptor tyrosine kinase activity; translocation mutation t(9;22)
Cancer associated with ABL mutation
CML (philadelphia chromosome)
MYC
Proto-oncogene that functions in nuclear transcription; translocation t(8;14)
Cancer associated with MYC mutation
Burkitt's Lymphoma
N-MYC
Proto-oncogene that functions in nuclear transcription; amplification mutation
Cancer associated with N-MYC mutation
Neuroblastoma
APC
Tumor Suppressor Gene that functions to prevent nuclear transcription (degrades catenin)
Cancer associated with APC
Familial Polyposis (colorectal cancer)
BRCA-1/BRCA-2
TSG that regulates DNA repair; associated with breat, ovarian, and prostate carcinoma
RB
TSG that inhibits G1 to S phase; associated with retinoblastoma, osteogenic sarcoma, and breast carcinoma
TGF-beta
TSG that inhibits G1 to S phase; associated with pancreatic and colorectal carcinomas
p53
TSG that inhibits G1 to S phase and also repairs DNA, activates BAX gene, and initiates apoptosis
Cancers associated with p53
Lung, colon, breast carcinomas, Li-Fraumeni syndrome (breast, brain, leukemia, sarcomas)
VHL
TSG that regulates nuclear transcription; associated with Von Hippel Lindau sydrome (cerebellar hemangiosarcoma, retinal angioma, renal adenocarcinoma, and pheochromocytoma)
WT1
TSG that regulates nuclear transcription; associated with Wilm's tumor
Mechanism of action for mutations of tumor suppressor genes
point mutation