Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
SIS
|
Proto-oncogene that function in growth factor synthesis; overexpression mutation
|
|
|
Cancers associated with SIS mutation
|
osteogenic sarcoma or astrocytoma
|
|
|
HER(ERB-B2)
|
Proto-oncogene that functions in receptor synthesis; amplification mutation
|
|
|
HER/ERB-B2 mutation causes what cancer
|
Breat carcinoma
|
|
|
RET
|
Proto-oncogene that functions in receptor synthesis; point mutation
|
|
|
Cancer associated with RET mutation
|
MEN IIa/IIb
|
|
|
RAS
|
Proto-oncogene that functions in GTP-signal transduction; point mutation
|
|
|
Cancers associated with RAS mutation
|
Leukemia, lung, colon, pancreatic carcinomas
|
|
|
ABL
|
Proto-oncogene that functions in nonreceptor tyrosine kinase activity; translocation mutation t(9;22)
|
|
|
Cancer associated with ABL mutation
|
CML (philadelphia chromosome)
|
|
|
MYC
|
Proto-oncogene that functions in nuclear transcription; translocation t(8;14)
|
|
|
Cancer associated with MYC mutation
|
Burkitt's Lymphoma
|
|
|
N-MYC
|
Proto-oncogene that functions in nuclear transcription; amplification mutation
|
|
|
Cancer associated with N-MYC mutation
|
Neuroblastoma
|
|
|
APC
|
Tumor Suppressor Gene that functions to prevent nuclear transcription (degrades catenin)
|
|
|
Cancer associated with APC
|
Familial Polyposis (colorectal cancer)
|
|
|
BRCA-1/BRCA-2
|
TSG that regulates DNA repair; associated with breat, ovarian, and prostate carcinoma
|
|
|
RB
|
TSG that inhibits G1 to S phase; associated with retinoblastoma, osteogenic sarcoma, and breast carcinoma
|
|
|
TGF-beta
|
TSG that inhibits G1 to S phase; associated with pancreatic and colorectal carcinomas
|
|
|
p53
|
TSG that inhibits G1 to S phase and also repairs DNA, activates BAX gene, and initiates apoptosis
|
|
|
Cancers associated with p53
|
Lung, colon, breast carcinomas, Li-Fraumeni syndrome (breast, brain, leukemia, sarcomas)
|
|
|
VHL
|
TSG that regulates nuclear transcription; associated with Von Hippel Lindau sydrome (cerebellar hemangiosarcoma, retinal angioma, renal adenocarcinoma, and pheochromocytoma)
|
|
|
WT1
|
TSG that regulates nuclear transcription; associated with Wilm's tumor
|
|
|
Mechanism of action for mutations of tumor suppressor genes
|
point mutation
|
