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38 Cards in this Set
- Front
- Back
- 3rd side (hint)
Tumor Suppressors + function
(10) |
Rb - cell cycle regulator
p53 - transcription factor Smads - transcription factor related to TGF-beta singnaling BRCA1,BRCA2 - DNA repair proteins APC - inhibitor of beta catenin in the Wnt-catenin signaling PTEN - phosphotase P16 -(in Rb pathway)- inhibitor of cycline dependent kinase XP WT1 |
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Oncogenes
(8) |
ErbB-2
HER2 Neu bcr abl src ras myc |
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Transcription Factor Oncogenes
(2) |
c-myc
n-myc |
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Tumor Suppressors
G1/S check point (2) |
Rb
p53 |
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Tumor Suppressors
DNA repair (3) |
BRCA1. BRCA2
XP |
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Growth Factor Receptor Oncogenes (3)
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erbB-2
HER2 Neu |
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Signaling Molecule Oncogenes
(5) |
Src
Abl Bcr-Abl Ras Bcl-2 |
Src - tyk non receptor
Abl - tyk non receptor Bcr-Abl - t(9:22) in CML Ras - gtp binding protein Bcl-2 - t(14:18) b cell lymphoma |
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Tumor Suppresor
Transcription factor (1) |
WT1
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fos
jun myc |
oncogene
transcription factors |
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c-myc
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oncogene
transcription factors found in Burkitts Lymphoma |
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bcl-1
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oncogene
cyclin D found in Mantle Cell Lymphoma |
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n-myc
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oncogene
transcription factor found in Neuroblastoma |
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Rb
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tumor suppressor
G1/S check point- normally regulates cell cycle by binding to E2F transcription factor which prevents binding to promoters of protooncogenes ex. c-myc 13q found in retinoblastoma before 5yo, when deletions/mutations occur |
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p53
targets of p53? (3) p53 degraded by? (1) |
tumor suppressor, "guardian of the genome"
G1/S check point, regulates through transcription regulation 17p found in most cancers, Li Fraumeni syndrome |
P53 targets
p21--> cell cycle arrest Bax --> apoptosis GADD45 --> DNA repair MDM2 --> degrades p53 |
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BRCA1
BRCA2 |
tumor suppressor
DNA repair 17q, 13q founding Breast Cancer and Ovarian Cancer |
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XP
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tumor suppressor
DNA repair found in Xenoderma Pigmentosum |
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WT1
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tumor suppressor
transcription factor 11p found in Wilms tumor |
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erbB-2
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oncogene
growth factor receptor tyrosine kinase |
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HER2
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oncogene
growth factor receptor tyrosine kinase found in Breast Cancer |
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Neu
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oncogene
growth factor receptor tyrosine kinase found in Breast Cancer |
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Src
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oncogene
signaling molecule tyrosine kinase non receptor=has the intracellular domain but NOT the receptor SH3SH2 domain is important for activation |
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Abl
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oncogene
signaling molecule tyrosine kinase non receptor t(9:22) philly chromosome, found in CML |
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Bcr-Abl
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oncogene
signaling molecule t(9:22) philly chromosome, found in CML -has potent tyrosine kinase activity |
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Ras
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oncogene
signaling molecule GTP binding protein -mediates cell responses via protein kinase pathways One mutation on codon 12,13,61 can turn on oncogene -activated ras found in 30% of all human cancers |
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Bcl-2
mech? found in? |
oncogene
signaling molecule/anti apoptotic t(14:18) -controls membrane permaeability Can be pro cell death or pr survival, BH3 only are pro death -Found in B follicular lymphoma |
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erbB-2/Neu/HER2
activation? pathway? |
Activated by heterodimerization with other erbB-2 proteins --> auto phosphorylation-->gene transcription via Ras pathway
ErbB-2 amplification is sene in breast cancer |
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Bcl-2 Family
pro-survival? (2) pro death? (2) |
Bcl-2 & Bcl-XL
Bax & Bad |
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Bcl-2 Family
death mech? |
Death receptor (TNF alpha receptor) activates Caspase 8 causes leaky mito, mito relases cytochrome C, binds, creates apoptosome, activates Caspsae 9, which activates Caspase 3, which degrades intracellular proteins
** 3 is the major executor=the grim reaper** |
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Bcl-2 Family
Effector caspases? Initiator caspases? |
Effector=death executors=3,6,7
Initiator=death organizers=2,8,9,10 |
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proto oncogenes?
(3) |
cyclin D
CDK4 E2F |
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Rb, p53 inactivated by ____??
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E6 inactivates p53
E7 inactivates Rb |
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TGF-Beta, Smad relationship, results?
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TGF-B binding activates TGF-B receptors-->activares Smad transcription factors--->Smad proteins, which regulate gene expression.
TGF-B/Smad=tumor suppressor pathway |
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Smad 4
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tumor suppressor, mutatedin 50% of pancreatic cancers
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Beta-Catenin
works with? |
A transcription factor
-works with Wnt, pro-proliferation Apc-tumor suppressor |
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Mech of APC/Wnt/B-catenin
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Without Wnt signal, B-catenin is usually degraded by APC. However, Wnt causes an inactivation of the APC destruction complex--> higher B catenin levels--> transcription
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APC
mutations? |
APC=tumor suppressor
-muataions causes high levels of B-catenin=increased transcription -causes Familial adenomatous polyposis |
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Src
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Src=proto onco gene, found in variety of cancers
-demonstrated oncogenic virus in chickens |
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PTEN
opposes? |
PTEN=phosphoase=tumor suppressor
-opposes PI3K-AKT oncogenic pathway |
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