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38 Cards in this Set

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Tumor Suppressors + function
(10)
Rb - cell cycle regulator
p53 - transcription factor
Smads - transcription factor related to TGF-beta singnaling
BRCA1,BRCA2 - DNA repair proteins
APC - inhibitor of beta catenin in the Wnt-catenin signaling
PTEN - phosphotase
P16 -(in Rb pathway)- inhibitor of cycline dependent kinase
XP
WT1
Oncogenes
(8)
ErbB-2
HER2
Neu
bcr
abl
src
ras
myc
Transcription Factor Oncogenes
(2)
c-myc
n-myc
Tumor Suppressors
G1/S check point
(2)
Rb
p53
Tumor Suppressors
DNA repair
(3)
BRCA1. BRCA2
XP
Growth Factor Receptor Oncogenes (3)
erbB-2
HER2
Neu
Signaling Molecule Oncogenes
(5)
Src
Abl
Bcr-Abl
Ras
Bcl-2
Src - tyk non receptor
Abl - tyk non receptor
Bcr-Abl - t(9:22) in CML
Ras - gtp binding protein
Bcl-2 - t(14:18) b cell lymphoma
Tumor Suppresor
Transcription factor
(1)
WT1
fos
jun
myc
oncogene
transcription factors
c-myc
oncogene
transcription factors
found in Burkitts Lymphoma
bcl-1
oncogene
cyclin D
found in Mantle Cell Lymphoma
n-myc
oncogene
transcription factor
found in Neuroblastoma
Rb
tumor suppressor
G1/S check point- normally regulates cell cycle by binding to E2F transcription factor which prevents binding to promoters of protooncogenes ex. c-myc
13q
found in retinoblastoma before 5yo, when deletions/mutations occur
p53
targets of p53? (3)
p53 degraded by? (1)
tumor suppressor, "guardian of the genome"
G1/S check point, regulates through transcription regulation
17p
found in most cancers, Li Fraumeni syndrome
P53 targets
p21--> cell cycle arrest
Bax --> apoptosis
GADD45 --> DNA repair

MDM2 --> degrades p53
BRCA1
BRCA2
tumor suppressor
DNA repair
17q, 13q
founding Breast Cancer and Ovarian Cancer
XP
tumor suppressor
DNA repair
found in Xenoderma Pigmentosum
WT1
tumor suppressor
transcription factor
11p
found in Wilms tumor
erbB-2
oncogene
growth factor receptor
tyrosine kinase
HER2
oncogene
growth factor receptor
tyrosine kinase
found in Breast Cancer
Neu
oncogene
growth factor receptor
tyrosine kinase
found in Breast Cancer
Src
oncogene
signaling molecule
tyrosine kinase non receptor=has the intracellular domain but NOT the receptor
SH3SH2 domain is important for activation
Abl
oncogene
signaling molecule
tyrosine kinase non receptor
t(9:22) philly chromosome, found in CML
Bcr-Abl
oncogene
signaling molecule
t(9:22) philly chromosome, found in CML
-has potent tyrosine kinase activity
Ras
oncogene
signaling molecule
GTP binding protein
-mediates cell responses via protein kinase pathways
One mutation on codon 12,13,61 can turn on oncogene
-activated ras found in 30% of all human cancers
Bcl-2
mech?
found in?
oncogene
signaling molecule/anti apoptotic
t(14:18)
-controls membrane permaeability
Can be pro cell death or pr survival, BH3 only are pro death
-Found in B follicular lymphoma
erbB-2/Neu/HER2
activation?
pathway?
Activated by heterodimerization with other erbB-2 proteins --> auto phosphorylation-->gene transcription via Ras pathway
ErbB-2 amplification is sene in breast cancer
Bcl-2 Family
pro-survival? (2)
pro death? (2)
Bcl-2 & Bcl-XL

Bax & Bad
Bcl-2 Family
death mech?
Death receptor (TNF alpha receptor) activates Caspase 8 causes leaky mito, mito relases cytochrome C, binds, creates apoptosome, activates Caspsae 9, which activates Caspase 3, which degrades intracellular proteins
** 3 is the major executor=the grim reaper**
Bcl-2 Family
Effector caspases?
Initiator caspases?
Effector=death executors=3,6,7

Initiator=death organizers=2,8,9,10
proto oncogenes?
(3)
cyclin D
CDK4
E2F
Rb, p53 inactivated by ____??
E6 inactivates p53

E7 inactivates Rb
TGF-Beta, Smad relationship, results?
TGF-B binding activates TGF-B receptors-->activares Smad transcription factors--->Smad proteins, which regulate gene expression.
TGF-B/Smad=tumor suppressor pathway
Smad 4
tumor suppressor, mutatedin 50% of pancreatic cancers
Beta-Catenin
works with?
A transcription factor
-works with Wnt, pro-proliferation
Apc-tumor suppressor
Mech of APC/Wnt/B-catenin
Without Wnt signal, B-catenin is usually degraded by APC. However, Wnt causes an inactivation of the APC destruction complex--> higher B catenin levels--> transcription
APC
mutations?
APC=tumor suppressor
-muataions causes high levels of B-catenin=increased transcription
-causes Familial adenomatous polyposis
Src
Src=proto onco gene, found in variety of cancers
-demonstrated oncogenic virus in chickens
PTEN
opposes?
PTEN=phosphoase=tumor suppressor

-opposes PI3K-AKT oncogenic pathway