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16 Cards in this Set
- Front
- Back
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DNA acting drugs |
Cisplatin, Cyclophosphoramide, Nitrosurea All act to form cross linking of DNA to prevent DNA synthesis and cell proliferation |
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Cisplatin |
DNA-acting drug - Makes reactive platinum complexes that cause cross linking Ototoxicity and nephrotoxicity |
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Cyclophosphoramide |
DNA-acting drug - induces alkyl radicals to DNA to cause cross linking Hemorrhagic cystitis |
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Antimetabolite drugs |
Methotrexate, 5-fluororacil, gemcitabine Mucositis, diarrhea, liver and kidney toxicity |
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5-fluorouracil |
Antimetabolite drug - inhibits thymidylate synthase Mucositis, diarrhea, liver and kidney toxicity |
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Gemcitabine |
Antimetabolite drug - Incorporates into DNA to inhibit synthesis Mucositis, diarrhea, liver and kidney toxicity Fever within 6-12hrs of 1st dose |
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Doxorubicin |
Natural product drug - Topoisomerase II inhibitor Dilated cardiomyopathy |
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Antimitotic drugs |
Vincristine, Vinblastine, Paclitaxel |
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Paclitaxel |
Antimitotic drug - blocks mitotic spindle function Hand/toes paresthesia |
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Vincristine |
Antimitotic drug - binds tubulin to prevent separation during metaphase Induced peripheral neuropathy |
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Vinblastine |
Antimitotic drug - inhibits MT dynamics Constipation, weakness, loss of appetite, GI problems |
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Prednisone |
Steroid drug - mechanism unknown Osteoporosis, gastritis/gastric ulcers, mood swings, hypertension |
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Aromatase inhibitors |
Anti-estrogen drugs - breast tissue is stimulated by estrogens so this takes away stimulation for breast tissue Osteoporosis and risk of joint disorders, infertility, aggression |
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Antiestrogen drugs |
Aromatase inhibitors and tamoxifen |
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Tamoxifen |
Anti-estrogen drug - competitively binds to estrogen receptor Menopausal symptoms, fluid retention venous clots |
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Interferon drugs |
Activate NK cells to mount big immune responses and used for women who can't take other drugs b/c of pregnancy |
