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56 Cards in this Set
- Front
- Back
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Paclitaxel, taxols mech
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Inhibits tubullin
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Paclitaxel, taxols clin
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Ovarian, breast
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Paclitaxel, taxols tox
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Myelosuppression
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Vincristine, Vinblastine mech
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Inhibit MTs
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Vincristine, Vinblastine clin
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Lymphoma
Wilm's tumor Choriocarcinoma |
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Vincristine, Vinblastine tox
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Vincristine- neurotox
Vinblastine- BLASTS BM |
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Imitinib (Gleevec) mech
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Philadelphia TK inhibitor
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Imitinib (Gleevec) clin
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CML
GI stromal tumors |
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Imitinib (Gleevec) tox
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Fluid retention
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Trastuzumab (Herceptin) mech
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Ab HER-2 (erb-B2)
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Trastuzumab (Herceptin) tox
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Cardiotox
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Tamoxifen, Raloxifene mech
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Blocks estrogen in breast,
Agonist in bone |
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Tamoxifen, Raloxifene tox
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Tamoxifen- may increase endometrial carcinoma, not Raloxifene
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Prednisone mech
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Apoptosis
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Prednisone Clin
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CLL
Hodgkin's |
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Etoposide (VP-16) mech
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Blocks topo II
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Etoposide (VP-16) clin
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Small Cell Carcinoma
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Etoposide (VP-16) tox
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Myelosuppression,
Alopecia |
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Hydroxyurea mech
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Inhibits ribonucleotide reductase
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Hydroxyurea clin
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Melanoma
CML Sickle cell |
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Hydroxyurea tox
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BM suppression
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Bleomycin mech
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Free radicals, DNA
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Bleomycin clin
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Hodgkin's
Testicular cancer |
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Bleomycin tox
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Pulmonary fibrosis***
Skin change not too much BM suppression |
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Dactinomycin (Actinomycin D) mech
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Intercalates
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Dactinomycin (Actinomycin D) clin
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Wilm's
Ewing's Rhabdomyosarcoma |
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Dactinomycin (Actinomycin D) tox
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BM supression
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Doxorubicin, Daunorubicin mech
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Free radical,
Intercalates |
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Doxorubicin, Daunorubicin clin
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Hodgkin's
Myelomas Sarcomas |
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Doxorubicin, Daunorubicin tox
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Cardiotox
BM suppression Allopecia |
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Busulfan mech
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Alkylates DNA
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Busulfan clin
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CML
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Busulfan tox
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Pulmonary fibrosis***
Hyperpigmentation |
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Cisplatin, Carboplatin mech
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Alkylate DNA
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Cisplatin, Carboplatin clin
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Testicular
Bladder Ovary Lung |
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Cisplatin, Carboplatin tox
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Nephrotoxicity
Acoustic nerve |
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Nitrosoureas- Carmustine, Lomustine, Semustine, Streptozocin- mech
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Alkylate DNA
BBB- requires bioactivation |
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Nitrosoureas- Carmustine, Lomustine, Semustine, Streptozocin- clin
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Brain tumors
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Cyclophosphamide, Ifosfamide mech
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Alkylates
Crosslinks at N-7 Requires bio-activation in the liver |
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Cyclophosphamide, Ifosfamide clin
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Non-Hodgkin's
Breast, ovarian Immunosuppression |
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Cyclophosphamide, Ifosfamide tox
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BM suppression
Hemorrhagic cystitis- mesna prevents |
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Cytarabine (ara-C) mech
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Inhibits DNA polymerase
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Cytarabine (ara-C) clin
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AML
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Cytarabine (ara-C) tox
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Leukopenia
Thrombocytopenia Megaloblastic anemia |
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6-Mercaptopurine mech
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Inhibits de novo purine synthesis
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6-Mercaptopurine clin
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Leukemias, Lymphomas
(not CLL, Hodgkin's) |
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6-Mercaptopurine tox
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BM, GI, liver
Met by xanthine oxidase- up tox with allopurinol |
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5-FU mech
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Antimetabolite
Inhibits thymidylate synthase |
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5-FU clin
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Colon cancer
BCC |
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5-FU tox
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BM suppression, IRREVERSIBLE
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Methotrexate mech
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Inhibits dihdrofolate reductase
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Methotrexate clin
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Leukemias, Lymphomas
Choriocarcinoma, Sarcoma Abortion, Ectopic preg, RA Psoriasis |
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Methotrexate tox
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BM suppression- reversed with Leucovorin
Fatty liver Mucositis |
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Clopidogrel, Ticlopidine mech
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Inhibits ADP receptors
Decreased IIb/IIIa expression |
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Clopidogrel, Ticlopidine clin
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Acute coronary
Decreased stroke risk |
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Clopidogrel, Ticlopidine tox
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Neutropenia
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