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15 Cards in this Set
- Front
- Back
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Etoposide
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MECHANISM:
TP-2 inhibitor. ATP-dependent. * Renal clearance (liver failure not an issue) TOXICITY: Secondary Leukemia |
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Gemcitabine
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MECHANISM:
Antimetabolite TOXICITY: Myelosuppression |
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Irinotecan
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MECHANISM:
TP-1 inhibitor. ATP-independent. |
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Topotecan
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MECHANISM:
TP-1 inhibitor. ATP-independent. |
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Campthecin
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MECHANISM:
TP-1 inhibitor. ATP-independent. |
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Cisplatin
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MECHANISM:
DNA cross-linking agent --> apoptosis *** renal clearance TOXICITY: Secondary Leukemia, Renal |
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Doxorubicin
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MECHANISM:
TP-2 inhibitor. ATP-dependent. - type of Anthracycline TOXICITY: Cardiac!, myelosuppression |
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Paclitaxel
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MECHANISM:
Antimitotic. Disrupts microtubules TOXICITY: Myelosuppression, hypersensitivity |
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Trastuzumab
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MECHANISM:
Hormone therapy/Growth Factor Inhibitor Ab causing downregulation of HER-2 receptors TOXICITY: Congestive Heart Failure |
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Bevacizimab
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MECHANISM:
Growth Factor Inhibitor Anti-angiogenesis via VEGF Ab's TOXICITY: Bleeding rxns in organs (ie. GI perforation, hemoptysis, etc.), first-dose infusion reaction |
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Imatinib
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MECHANISM:
Growth Factor Inhibitor (RTK) Prevention of phosporylation of BCR-ABL mutation product in 9:22 leukemia. (therefore prevents survival and proliferation pathways) TOXICITY: - |
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Erlotinib
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MECHANISM:
Growth Factor Inhibitor Prevents dimerization of EGFR (an RTK) * clearance with CYP3A4 TOXICITY: dermititis, dry skin, rare MI |
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Sorafenib
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MECHANISM:
Growth Factor Inhibitor inhibits kinases TOXICITY: hypertension, hand/foot syndrome, increased amylase and lipase |
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Sirolimus (Rapamycin)
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MECHANISM:
Growth Factor Inhibitor inhibits mTOR (which leads to mRNA translation) TOXICITY: anemia, thrombocytopenia, *Immunosuppression (therefore infection with CMV, PCP), hypertension |
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Vincristine
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Antimitotic. Blocks elongation of tubules
Cause peripheral neuropathy |
