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23 Cards in this Set
- Front
- Back
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Vincristine
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Mitotic Spindle Poison, prevents microtubules from forming--> thus stopping the mitotic spindle. Causes peripheral neuropathy
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Paclitaxel
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Mitotic Spindle Poison. Prevents Microtubule dissociation freezing the spindle in place. Causes peripheral neuropathy
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Cyclophosphamide
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Mustard Gas prototype. Binds DNA, prevents transcription and duplication. Need P450 to be activated. Very Immunosupressive
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Cisplatin
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DNA alkylating agent.Ditrubutes into tissues better than cyclophosphamide.
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Doxorubican=adrimycin
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Topoisomerase inhibitor. Used in breast cancer. Break dna when topoisomerase tries to unwind it. Cardiac toxicity common.
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5-floro-uracil
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5FU prevents thymidilate synthetase from adding a methy group to uricil, thus creating thymidilate. All serves to slow transcription.
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Methotrexate
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Methotrexate inhibits dihidrofolate reductase, inhibiting the formation of THF that donates the methyl group for thymidilate synthatase.
Slows transcription |
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Bevacizumab
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VEGF Target-er. O2 drops in tumor, VEGF gets released, causes angiogenesis. $70,000, 5 month improvement. Causes Hypertension. Signifigant Use in Macular Degeneration.
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Cetuximab
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Anti EGFR (=HER1) antibody. Often used for corectal cancer. Works better in wild type Ras population.
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Traetuzumab
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Anti HER2 Antibody--> Her-2 mutation bad news in breast cancer, but signifies weakness to Drug. Causes cardiac side effects.
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Rituximab
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Anti CD20 B Cell antigen, Leukemias Probably
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Geftinib, Erlotinib
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EGFR- Kinase inhibitor. Resistnce caused by a mutation in T790M. Cause itchiness like Cetuximab, same Ras relationship as well.
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Lapatinib
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Very Specific for Her-2 kinase
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Sorafenib, Sutinib
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VEGFR-r internal kinase targeter. Thats it.
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Imatinib
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Abl/Bcr targeter. Great at first but resistance is likely.
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Vemurafenib
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Targets BRaf which is downstream of Ras. Used in metastatic melanoma. Only really gives you like 6 more weeks
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Ipilimunab
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Blocks the CTLA4 receptor on T cells so that tumor cells can't use it to suppress growth. Anti PD-1 does a similar thing to PD1. Also used in Metastatic Melanoma. Inflammatory, autoimmune side effects.
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Bortezomib
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Proteasome ihibitor. Cells cannot degrate protein and become apoptotic. Does cause system wide side effects, good additional drug.
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Azathioprine
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T cell cycle inhibitor,
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Sirolimus
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Interferes with IL-2 pathway in T Cell
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Cyclosporine/Tacrolimus
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Interferes with calcenurin transduciton of the TCR pathway.
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Basiliximab, Daclizumab
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Anti IL2-R antibody.
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Infliximab
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Anti TNF antibody
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