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41 Cards in this Set

  • Front
  • Back
forms complex between topoisomerase II and DNA
etoposide, teniposide
alkylates DNA
toxicity-->pulmonary fibrosis
busulfan
fragments DNA
toxicity-->pulmonary fibrosis
bleomycin
blocks purine synthesis
metabolized by xanthine oxidase
6-mercaptopurine
Crosslinks DNA
nephrotoxic, ototoxic
cisplatin, carboplatin
Nitrogen mustard
alkylates DNA (electrophil that binds DNA)
cyclophosphamide
folic acid analog
inhibits dihydrofolate reductase
methotrexate
prevent tubulin disassembly
taxols
intercalates DNA
produces oxygen free radicals
cardiotoxic
doxorubicin
daunorubicin
DNA alkylating agents used in brain cancer
nitrosoureas
prevents tubulin assembly
vincristine, vinblastine
("blast" the cells "vines"/microtubules before they assemble)
inhibits thymidylate synthase-->decreased nucleotide synthesis
5-fluorouracil
SERM: blocks estrogen binding to estrogen receptor positive cells
tamoxifen, raloxifene
mechanism similar to the antivirals acyclovir and foscarnet
cytarabine
mechanism similar to fluoroquinolones
etoposide, teniposide
mechanism similar to trimethoprim
methotrexate
monoclonal antibodies against HER-2 (erb-B2)
trastuzumab
free radical induced DNA strand breakage
bleomycin, doxorubicin, daunorubicin
inhibitor of PRPP synthetase
6-mercaptopurine
reversible with leucovorin
methotrexate
treatment for choriocarcinoma
methotrexate, vincristine, vinblastine
treatment for AML
cytarabine, sometimes imatinib
treatment for CML
imatinib, busulfan
prevents breast cancer
tamoxifen, raloxifene
treatment for testicular cancer
etoposide, bleomycin, cisplatin
"eradicate ball cancer"
applied topically for actinic keratoses and basal cell cancers
5-fluorouracil
treatment for childhood tumors (Ewing's sarcoma, Wilm's tumor, rhabdomyosarcoma)
dactinomycin
(kids ACT out)
inhibits ribonucleotide reductase
hydroxyurea
has SE of hemorrhagic cystitis
cyclophosphamide
antibody against Philadelphia chromosome
Imatinib
overdose "rescue" with thymidine
5-fluorouracil
has increased toxicity when given with allopurinol
6-mercaptopurine
same mechanism as 6-MP but can be given with allopurinol
6-thioguanine
toxic to tissues with extravasation
doxorubicin, daunorubicin
toxic metabolite that causes hemorrhagic cystitis when taking cyclophosphamide
acrolein
given with cyclophosphamide to help prevent hemorrhagic cystitis
mesna
can cross the blood brain barrier
nitrosoureas (therefore used for brain cancers)
also used in sickle cell disease to increase HbF
hydroxyurea
may trigger apoptosis; also helps chemotherapy induced nausea/vomiting
prednisone
Prednisone toxicity
Cushing-like symptoms
immunosuppression
cataracts
acne
osteoporosis
hypertension
peptic ulcers
hyperglycemia
psychosis
may be used as breast cancer prophylaxis in BRCA carriers
tamoxifen, raloxifene