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41 Cards in this Set
- Front
- Back
forms complex between topoisomerase II and DNA
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etoposide, teniposide
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alkylates DNA
toxicity-->pulmonary fibrosis |
busulfan
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fragments DNA
toxicity-->pulmonary fibrosis |
bleomycin
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blocks purine synthesis
metabolized by xanthine oxidase |
6-mercaptopurine
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Crosslinks DNA
nephrotoxic, ototoxic |
cisplatin, carboplatin
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Nitrogen mustard
alkylates DNA (electrophil that binds DNA) |
cyclophosphamide
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folic acid analog
inhibits dihydrofolate reductase |
methotrexate
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prevent tubulin disassembly
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taxols
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intercalates DNA
produces oxygen free radicals cardiotoxic |
doxorubicin
daunorubicin |
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DNA alkylating agents used in brain cancer
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nitrosoureas
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prevents tubulin assembly
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vincristine, vinblastine
("blast" the cells "vines"/microtubules before they assemble) |
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inhibits thymidylate synthase-->decreased nucleotide synthesis
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5-fluorouracil
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SERM: blocks estrogen binding to estrogen receptor positive cells
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tamoxifen, raloxifene
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mechanism similar to the antivirals acyclovir and foscarnet
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cytarabine
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mechanism similar to fluoroquinolones
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etoposide, teniposide
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mechanism similar to trimethoprim
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methotrexate
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monoclonal antibodies against HER-2 (erb-B2)
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trastuzumab
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free radical induced DNA strand breakage
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bleomycin, doxorubicin, daunorubicin
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inhibitor of PRPP synthetase
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6-mercaptopurine
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reversible with leucovorin
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methotrexate
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treatment for choriocarcinoma
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methotrexate, vincristine, vinblastine
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treatment for AML
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cytarabine, sometimes imatinib
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treatment for CML
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imatinib, busulfan
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prevents breast cancer
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tamoxifen, raloxifene
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treatment for testicular cancer
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etoposide, bleomycin, cisplatin
"eradicate ball cancer" |
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applied topically for actinic keratoses and basal cell cancers
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5-fluorouracil
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treatment for childhood tumors (Ewing's sarcoma, Wilm's tumor, rhabdomyosarcoma)
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dactinomycin
(kids ACT out) |
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inhibits ribonucleotide reductase
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hydroxyurea
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has SE of hemorrhagic cystitis
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cyclophosphamide
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antibody against Philadelphia chromosome
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Imatinib
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overdose "rescue" with thymidine
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5-fluorouracil
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has increased toxicity when given with allopurinol
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6-mercaptopurine
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same mechanism as 6-MP but can be given with allopurinol
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6-thioguanine
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toxic to tissues with extravasation
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doxorubicin, daunorubicin
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toxic metabolite that causes hemorrhagic cystitis when taking cyclophosphamide
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acrolein
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given with cyclophosphamide to help prevent hemorrhagic cystitis
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mesna
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can cross the blood brain barrier
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nitrosoureas (therefore used for brain cancers)
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also used in sickle cell disease to increase HbF
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hydroxyurea
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may trigger apoptosis; also helps chemotherapy induced nausea/vomiting
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prednisone
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Prednisone toxicity
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Cushing-like symptoms
immunosuppression cataracts acne osteoporosis hypertension peptic ulcers hyperglycemia psychosis |
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may be used as breast cancer prophylaxis in BRCA carriers
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tamoxifen, raloxifene
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