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36 Cards in this Set
- Front
- Back
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inhibit dihydrofolate reductase --> dTMP
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methotrexate
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leucovorin rescue
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MTX
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inhibits thymidylate synthase
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5- FU
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rescue w/ thymidine
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5-FU
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for actinic keratosis or basal cell carcinoma
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5-FU
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cancer drug for uterine pathology
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methotrexate
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6-MP is activated by
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HGPRT synthase
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6-MP is metabolized by
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xanthine oxidase
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6-MP acts on
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PRPP synthase
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cancer drug that inhibits DNA polymerase
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cytarabine
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cancer drug similar to acyclovir, foscarnet
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cytarabine
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Dactinomycin MOA
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intercalates
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Doxorubinc MOA
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free radicals, intercalates
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bleomycin MOA
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free radicals
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etoposide, teniposide MOA
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inhibit topoisomerase II
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fragments DNA w/ pulmonary fibrosis
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bleomysin
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akylates DNA w/ pulmonary fibrosis
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busulfan
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cyclophosphamide MOA
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covalently link at guanine N-7
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SE = hemorrhagic cystitis
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cyclophosphamide
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cancer drug for brain tumors
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nitroureas
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nitrosoureas - drug names
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"mustine", streptozocin
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cancer drug that passes BBB
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nitroureas
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cancer drug for CML
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busulfan
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busulfan MOA
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alkylates
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cancer drug for AML
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cytarabine, 6- TG
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blocks polyermization of MTs
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vinchristine
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hyperstabilizes MTs
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taxols
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drugs for testicular cancer
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etoposide, bleomycin, cyclophosphamide
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for childhood tumors
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dactinomycin
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SE of cisplatin
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nephrotox + acoutic nerve damage
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hydroxyurea MOA
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inhibit ribonucleotide reductase
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side effects of prednisone
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cushing's like, HTN, hyperglycemia, psychosis, insomnia, cataracts, acne, immunosuppression, osteoporosis, peptic ulcers
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tamoxifen, raloxifene
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SERMS- receptor antagonists @ breast + agonist @ bone
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Ab against HER-2
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trastuzumab
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Imatinib MOA
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bcr-abl tyrosine kinase inhibitor
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Ab against CD 20
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rituximab
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