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30 Cards in this Set
- Front
- Back
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Dog breeds predisposed to lymphoma |
boxers, bull mastiffs, basset hounds, Saint Bernards, bulldogs, airedale terriers |
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Which lymphoma location types are typically T-cell? |
Mediastinal, cutaneous |
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What are the clinical signs of the paraneoplastic syndrome that is due to lymphoma? |
Anemia, fever, thrombocytopenia, hypercalcemia, monoclonal gammopathy, cachexia |
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if you want to biopsy a lymph node of the head and neck, which ones should you avoid? |
mandibular lymph nodes |
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FNA can get you a sample for which two diagnostic modalities? |
Cytology, flow cytometry |
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What is the purpose of doing PARR (pcr)? |
Immunophenotyping, distinguishing clonality v. hyperplasia or if its chronic or mild, and for monitoring effect of therapy |
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What are the IHC/ICC markers for T and B cells? |
T cells = CD3, B cells= CD79, CD20 |
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What are the flow cytometry markers for B and T cells? |
B cell = CD 21, T cell= CD3, 4, 5 or 8 |
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What aspects of flow cytometry will have prognostic significance? |
homo/heterogeneity, weird marker expression, cell size |
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What staging system is used for lymphoma? |
WHO stages 1-5 |
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What do WHO stages 4 and 5 mean? |
4 means there is liver or spleen involvement, 5 means there is blood or bone marrow involvement |
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What are the prognostic factors for Lymphoma? |
stage, substage, anatomic location, steroid pre-treatment, histologic grade, immunophenotype, flow cytometry findings, chemo reaction in the blood |
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What things do you need to keep in mind when deciding to treat for lymphoma? |
stage, paraneoplastic syndromes, physiologic status, tolerance for toxicity, cost of therapy and time commitment |
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What is the survival time of a lymphoma patient that does not get treated? |
4-6 weeks |
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If you give only prednisone at appropriate doses what is the survival time? |
6-8 weeks |
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What is the chemo treatment of choice for lymphoma in dogs? |
CHOP protocol |
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If you achieve remission at 19 weeks on the CHOP protocol then what? |
stop chemo and re-assess monthly |
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If CHOP is too expensive what is a secondary protocol you can use to treat lymphoma? |
Doxorubicin with a 4 week tapering dose of prednisone |
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With the Doxo+pred protocol, what phenotype does it not work against? |
T cell phenotype, works for B cell though |
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With the doxo+pred protocol, If you achieve remission, how long will the remission last? |
4-5 month remission |
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What are the different rescue protocols for treating lymphoma? |
Put back on CHOP, CCNU+L-asparaginase, CCNU by itself |
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If you have to do a rescue protocol, about how long do patients respond to the rescue treatment? |
1.5-2.5 months |
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What do you need to do to monitor your chemo patients? |
Physical exam, CBC/Chem, u/a at EVERY visit! |
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Should you treat axillary maladies like a UTI during chemotherapy? |
YES, don't ignore unrelated medical issues |
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When should you use radiation to treat lymphoma? |
ask the oncologist, but this is a good option because lymphoma is sensitive |
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How do you treat cutaneous lymphoma? |
CCNU+ steroids, maybe whole body radiation, clean up other skin disease |
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how do you treat GI lymphoma in the dog? |
Modified CHOP protocol, but be prepared, chemo doesn't work super well here |
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How do you treat T cell lymphoma? |
CHOP or L-MOPP (alkylator heavy) |
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What is the survival times for T cell lymphoma treated with L-MOPP? |
270 days |
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What is the survival time for T-cell lymphoma treated with CHOP? |
250 days |
