Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
Mephalan
|
alkylating agent - multiple myeloma
|
|
|
Estramustine
|
alkylating agent - inhibits microtubule formation
|
|
|
Chlorambucil
|
alkylating agent with n-methyl group; decreased reactivity; oral administration; CLL
|
|
|
Cyclophosphamide/ifosfamide
|
alkylating agents; prodrugs; require cyt P450 activation; metabolite acrolein - chemical cysticis (give with mesna)
|
|
|
BCNU/CCNU
|
alkylators; nitrosureas; brain tumors
|
|
|
Mitomycin C
|
colon cancer; alkylating agent
|
|
|
Thiotepa
|
metabolized to tepa; alkylating agent; intrathecal for carcinomatous meningitis
|
|
|
busulfan
|
alkylating agent; selective toxicity for myeloid precursors (CML/AML); assoc. with pulmonary fibrosis
|
|
|
Procarbazine
|
binds DNA and causes single strand breaks; inhibits DNA, RNA, and protein synthesis; Hodgkins and NHL; resistance related to O6-alkyluanine-DNA-alkyltransferase
|
|
|
Dacarbazine
|
methylates DNA and causes breaks/damage; malignant melanoma, hodgkin's, sarcoma, neuroblastoma, brain tumors
|
|
|
Temozolomide
|
penetrates in the brain - used to treat gliomas
|
|
|
Cisplatin
|
emetogenic platinum compound
|
