Cancer Chemotherapy

Front 1

Vincristine

Back 1

inhibits microtubules, for NHL, ALL, neurotoxic, SIADH; metabolized by liver

Hint 1

Cris plays for NHL and got his brain injured

Front 2

Vinblastine

Back 2

inhibits microtubules, for HD, ALL, myelosuppressive; metabolized by liver

Front 3

Vinorelbine

Back 3

inhibits microtubules, for lymphomas, myelosuppressive; metabolized by liver

Front 4

Etopiside

Back 4

inhibits topoisomerase II; for lung, testes, lymp, peds; myelosuppressive

Front 5

Taxol

Back 5

inhibits microtubule depolymerization, for some GU and breast ca, myelosuppressive

Front 6

Taxotere

Back 6

inhibits microtubule depolymerization, for some GU and breast ca, myelosuppressive

Front 7

Irinotecan

Back 7

For colon cancer; inhibits topoisomerase I; causes diarrhea; prodrug

Hint 7

irene had to go to the can

Front 8

Doxorubicin (adriamycin)

Back 8

antibiotic for many cancers (not lung or colon); intercalates between DNA bases and interrupts RNA synthesis; forms free radicals (cardiac toxic) so give DEXRAZOXANE; myelosuppressive, strong emetic agent

Front 9

Daunorubicin (daunomycin)

Back 9

for AML/ALL, intercalates between DNA bases

Front 10

Dexrazoxane

Back 10

free radical scavenger; give with doxorubicin

Front 11

Asparaginase

Back 11

Enzyme that depletes L-asparagine; inhibits some liver fxn

Front 12

Allopurinol

Back 12

for tumor lysis syndrome/hyperuricemia; inhibits xanthine oxidase which catalyzes formation of uric acid

Front 13

Raspuricase

Back 13

for tumor lysis syndrome, hyperuricemia; turns uric acid to highly soluble allantoin

Front 14

5-fluorouracil

Back 14

continuous infusion inhibits thymidine production/DNA synthesis, gives mucositis; Bolus inhibits RNA and can cause myelosuppression. Either can cause for cardiac/hepatotoxicity. for breast, Colon, GI, bladder, breast, head and neck. prodrug converted to F-dUMP

Front 15

Cytarabine

Back 15

for AML/ALL, prodrug must be phosphorylated x3 to inhibit DNA polymerase (S); continuous IV infusion, myelosuppresive, high dose CNS and pulm toxic

Front 16

Gemcitibine

Back 16

for bladder, lung, pancreas; prodrug must be phosph x1 to terminate DNA strand formation; radiosensitizer; mild myelosuppression

Front 17

Methotrexate

Back 17

for bladder, lymphoma, brain, osteosarcoma, childhood; inhibits folic acid conversion (S), oral or IV or intrathecally, prodrug converted w/i cell, excreted renally, administer with LEUCORVIN to save nl tissue and lots of fluid

Front 18

Leucorvin

Back 18

give with metrotrexate to rescue nl cells. bypasses the blocked step in folate metabolism

Front 19

Ritixumab

Back 19

binds CD20, for CD20+ non-hodgkins lymphomas

Front 20

Cyclophosphamide

Back 20

alkylating agent with a broad range of activity. can be resisted in various ways. prodrug. moderate N/V, myelosuppression

Front 21

Ifosfamide

Back 21

akylating agent with broad activity, some N/V

Front 22

Cisplatin

Back 22

platinum based agent that disrupts DNA fxn. if extravasated, give Na Thiosulfate. Can cause renal insuff, so give lots of fluids and diurese. Major N/V

Front 23

Carboplatin

Back 23

platinum based agent that disrupts DNA fxn. Myelosuppression, moderate N/V, moderate nephrotoxicity

Front 24

Sodium thiosulfate

Back 24

antidote to cisplatin

Front 25

EPO

Back 25

for anemia due to cancer

Front 26

GM-CSF

Back 26

stimulates neutrophil and Eos production

Front 27

G-CSF

Back 27

stimulates neutrophil production

Front 28

Imatinib (Gleevec)

Back 28

for CML, GIST, Ph+ ALL. inhibits BCRabl tyrosine kinase/c-kit

Front 29

Tamoxifen

Back 29

for estrogen R positive breast cancer, blocks Receptor; increases chance of endometrial cancer, most commonly causes hot flashes, bone pain/hypercalcemia

Front 30

Flutamide

Back 30

antiandrogen for prostate cancer. can cause hepatotoxicity

Front 31

Leupromide

Back 31

GnRH analogue, for prostate cancer; first causes surge in FSH and LH so give with anti-androgen to avoid a flare-up/hot flashes