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20 Cards in this Set

  • Front
  • Back
what is hemostasis regulated by?
vascular wall
activity coagulation factors
this involves the defect in the intrinsic hemostatic mechanism
inherited x linked pattern - female pass to sons
prenatal diagnosis possible
how is hemophilia usually diagnosed in infancy
has bruising or bleeding after venipuncture or circumcision, concerns with abuse are common
what is the treatment for hemophilia
prophalaxis with clotting factor
which hemophilia is the most common form
hemophilia A - Factor VIII deficiency
what is the other name for Christmas Disease or Hemophilia B
factor IX deficiency
this is a deficiency that is common and inherited >1% of the population
von wilderbrand disease
what is the role in von wilder brand factor
mediates adhesions of platelets to sites of vascular injury, making it essential for platelet plug formation and functions as a carrier protein that stabilizes coagulation factor VIII
what is the treatment for von wilder brand disease
synthetic and plasma derived products
what are some red flag signs for neoplastic disease
mass/abdominal pain
unexplained increased bleeding or bruising
unexplained fevers
recurrent infections
pallor and fatigue
bone or limp pain
airway or UA obstruction
nonspecific symptoms - weight loss, diarrhea, FTT, malaise and low grade fevers
what are ACUTE SE of chemotherapy
myelosuppression - infection
allergic reaction
what are ACUTE SE of radiation therapy
skin and mucosal inflammation
tissue edema and inflammation
what are the later SE of cancer for CNS
neurocognitive - esp if CNS tumors or of the neck
developmental progress
academic achievement
visiual and perceptual motor skills
nonverbal and verbal memory
receptive and expressive language and attention
what are the later SE of cancer for psychosocial
simular to PTSD, avoid things that remind them of that time, experience increased sleep disturbance, irritability, hypervigalance, difficulty concentrating
what are common hearing and eye complications following cancer
hearing loss, esp of head or neck

sarcoma of the eye, cataract, retinopathy, optic neuropathy, lid lag, change in vision - with head and neck
what GI complications occur after cancer
teeth are brittle after chemo or radiation esp if after age 3 years old, change in salvation if salivary gland involved

Hepatotoxicity - chemo meds, related to cumulative dose, additional treatments, irradiated liver and hepatitis
what happens with a splenectomy
increased risk for infection, should have life long PCN or at first sign of fever and before dental
what cardiac complications occur after cancer
cardiac toxicity - pericarditis, myopathy, CAD, functional valve injury, conduction defects
what endocrine complications occur after cancer
most commonly hyper/hypo thyroid, goiter, or nodules, usually within the first 2 years post treatment

others: growth hormone, precocious puberty, cranial irradiation
what are common MS side effects after cancer
osteonecrosis, reduced bone density