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20 Cards in this Set
- Front
- Back
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what is hemostasis regulated by?
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vascular wall
platelets activity coagulation factors |
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this involves the defect in the intrinsic hemostatic mechanism
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Hemophilia
inherited x linked pattern - female pass to sons prenatal diagnosis possible |
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how is hemophilia usually diagnosed in infancy
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has bruising or bleeding after venipuncture or circumcision, concerns with abuse are common
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what is the treatment for hemophilia
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prophalaxis with clotting factor
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which hemophilia is the most common form
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hemophilia A - Factor VIII deficiency
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what is the other name for Christmas Disease or Hemophilia B
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factor IX deficiency
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this is a deficiency that is common and inherited >1% of the population
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von wilderbrand disease
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what is the role in von wilder brand factor
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mediates adhesions of platelets to sites of vascular injury, making it essential for platelet plug formation and functions as a carrier protein that stabilizes coagulation factor VIII
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what is the treatment for von wilder brand disease
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synthetic and plasma derived products
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what are some red flag signs for neoplastic disease
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mass/abdominal pain
lymphadenpathy unexplained increased bleeding or bruising unexplained fevers recurrent infections pallor and fatigue bone or limp pain leukoria hematuria airway or UA obstruction nonspecific symptoms - weight loss, diarrhea, FTT, malaise and low grade fevers |
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what are ACUTE SE of chemotherapy
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myelosuppression - infection
n/v alopecia mucositis CM neuropathy cystitis allergic reaction pancreatitis pneumonitis |
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what are ACUTE SE of radiation therapy
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skin and mucosal inflammation
tissue edema and inflammation pneumonitis n/v enteritis myelosuppression alopecia |
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what are the later SE of cancer for CNS
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neurocognitive - esp if CNS tumors or of the neck
include: intelligence developmental progress academic achievement visiual and perceptual motor skills nonverbal and verbal memory receptive and expressive language and attention |
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what are the later SE of cancer for psychosocial
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simular to PTSD, avoid things that remind them of that time, experience increased sleep disturbance, irritability, hypervigalance, difficulty concentrating
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what are common hearing and eye complications following cancer
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hearing loss, esp of head or neck
sarcoma of the eye, cataract, retinopathy, optic neuropathy, lid lag, change in vision - with head and neck |
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what GI complications occur after cancer
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teeth are brittle after chemo or radiation esp if after age 3 years old, change in salvation if salivary gland involved
Hepatotoxicity - chemo meds, related to cumulative dose, additional treatments, irradiated liver and hepatitis |
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what happens with a splenectomy
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increased risk for infection, should have life long PCN or at first sign of fever and before dental
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what cardiac complications occur after cancer
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cardiac toxicity - pericarditis, myopathy, CAD, functional valve injury, conduction defects
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what endocrine complications occur after cancer
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most commonly hyper/hypo thyroid, goiter, or nodules, usually within the first 2 years post treatment
others: growth hormone, precocious puberty, cranial irradiation |
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what are common MS side effects after cancer
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osteonecrosis, reduced bone density
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