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23 Cards in this Set
- Front
- Back
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Function of PTH?
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increase plasma Ca and decrease plasma PO4 by increasing bone deposition and resorption and increasing kidney resorption of Ca
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Fxn of vitamin D?
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increase plasma Ca and decrease plasma PO4 by increasing GI abs of both, increasing calcium bone deposition and resorption, increase renal reabsorption of Ca and PO4
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Fxn of calcitonin?
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DECREASE plasma Ca and PO4 by DECREASE Ca bone resorption, decrease renal reabsorption, decrease GI absorption
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Fxn of bisphosphanates (etidronate, pamidronate, alendronate, ibandronate, zoledronic acid, risedronate)?
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stabilize hydroxyapatite crystals in bone, DECREASE formation, growth, dissolution, bone turnover
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Fxn fluoride?
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accumulate in bones and teeth, stabilize hydroxyapatite
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Fxn glucocorticoids?
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DECREASE Ca abs in GI, INCREASE Ca excretion in kidney
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Fxn estrogens?
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inhibit bone resorption
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Fxn Ca preparations?
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used in prevention and treatment of Ca deficiency
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Fxn Cinacalcet?
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stimulate Ca receptors to DECREASE PTH
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What is used for treatment of chronic hypercalcemia, is anti-inflammatory and immunosuppressive?
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glucocorticoids
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Which drug stabilizes the calcium in teeth?
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Fluoride
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What is used to treat postmenopausal osteoporosis?
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estrogen
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What drug is at risk for causing esophageal perforation?
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alendronate
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PTH!
GI abs/kidney reabs/bone resorp/Ca Plasma? |
INCREASE ALL
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Vitamin D!
GI abs/kidney reabs/bone resorp/Ca Plasma? |
INCREASE ALL
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Calcitonin!
GI abs/kidney reabs/bone resorp/Ca Plasma? |
DECREASE ALL
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PTH on kidney?
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increase plasma calcium, decrease plasma PO4
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What is used to treat hypocalcemia associated with chronic renal failure
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calcitriol
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What is the most serious adverse reaction of Alendronate, when used in the treatment of osteoporosis?
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esophagitis
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What is the treatment for hypocalcemia?
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vitamin D
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What is the treatment for hypercalcemia?
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fluids, low calcium diet, etidronate, furosemide, glucocorticoids, calcitonin, cinacalcet
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What is the treatment for a bone disorder such as Paget's disease?
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bisphosphonates
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What is the treatment for remodelling disorder such as osteoporosis?
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calcitonin, plicamycin, alendronate, fluoride, teriparatide
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