Calcium Chloride

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CALCIUM CHLORIDE
Class/MOA

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Class
Electrolyte.
Mechanism of Action
Increases cardiac contractile state (positive inotropic effect).
May enhance ventricular automaticity.

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CALCIUM CHLORIDE
I/CI

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Indications
Hypocalcemia, magnesium sulfate overdose, hyperkalemia, calcium channel blocker
toxicity.
Adjunctive therapy in treatment of insect bites and stings.
Contraindications
Hypercalcemia, VF during cardiac resuscitation; digitalis toxicity.

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CALCIUM CHLORIDE
AR/DI

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Adverse Reactions
Bradycardia, asystole, hypotension, peripheral vasodilatation, metallic taste, local
necrosis, coronary and cerebral artery spasm, nausea, vomiting.
Drug Interactions
May worsen dysrhythmias secondary to digitalis.
May antagonize effects of Verapamil.
Flush line before and after administration of sodium bicarbonate.

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CALCIUM CHLORIDE
How supplied

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How Supplied
10% solution in 10 ml ampules, vials and prefilled syringes (100 mg/ ml).

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CALCIUM CHLORIDE
Dosages Admin

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Dosage and Administration
Adult: 2-4 mg/kg of 10% solution slowly IV over 5 minutes; may repeat in 10
minutes. (maximum: 1 gm dose)
Pediatric: 20 mg/kg/dose of 10% solution slow IV/ IO (maximum: 1 gm dose);
(may repeat in 10 minutes.)

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CALCIUM CHLORIDE
DOA/ Specials

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Duration of Action
Onset: 5-15 minutes.
Peak effects: 3-5 minutes.
Duration: 15-30 minutes but may persist for 4 hours (dose dependent).
Special Considerations
Pregnancy safety: Category C.
For pediatrics: if calcium gluconate is unavailable, 1-2 ml of 10% calcium chloride
solution, diluted with IV fluid, may be substituted.
DRUG