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22 Cards in this Set

  • Front
  • Back
Teripartide- Class, Use, MOA, PK, CI
Class: recombinant PTH
Use: osteoporosis
MOA: increases calcium absorption to bones
PK: low dose only, at high doses will cause bone loss b/c will cause increased release of calcium from bone
CI: hypersensitivity
Cholecalciferol, ergocalciferol- Class, MOA
Class: liver activated analog, liver will covert D3 adn D2 into 25(OH) D and store them, then the kidney will further activate (PTH controls this process)
Calcitriol- Class, Use, MOA
Class: vit D activated or liver activated analog
Use: hypocalcemia due to renal deficiency, 2ndary hyperparathyroidism
MOA: bypasses kidney activation, inhibits PTH secretion
Calcitriol, doxecalciferol-Tox
Tox: hypercalcemia, hyperphosphatemia, hypercalciuria
Paricalcitol- Class, Use, MOA, Tox
Class: VIt D activated or liver activated analog
Use: 2ndary hyperparathyroidism
MOA: bypasses kidney activation and inhibits PTH secretion
Tox: less vitamin D toxicity
Cinacalcet- Class, Use, MOA, Tox
Class: calcimimetics
Use: 2ndary hyperparathyroidism
MOA: increases sensitivity of the calcium sensing receptor to free Ca+ which in tunr lowers PTH output
Tox: sz, hypocalcemia
Calcitonin- Use, MOA
Use: Pagets Dz, hypercalcemia, osteoporosis
MOA: antagonizes PTH, acts at the calcitonin receptor to inhibit calcium intake into the gut and inhibits calcium release from bones, adn inhibit calcium and phosphate reabsorption by the kdiney
Prednisone- Class, Use, MOA
Class: glucocorticoids
Use: cancer associated hypercalcemia
MOA: antagonizes Vit D
Alendronate, pamidronate, risedronate- Class, Use, MOA, Tox
Class: bisphosphonates
Use: cancer associated hypercalcemia, osteoporosis, Pagets dz
MOA: inhibits osteoclasts,
Tox: erosive esophagitis, osteonecrosis of the jaw
Raloxifene- Class, Use, MOA, Tox/CI
Class: selective estrogen receptor modulators
Use: postmenopausal osteoporosis
MOA: agonist in bones, antagonist in uterus and breasts
Tox: hot flashes
CI: lactating or pregnant women or women w/ hx of thromboembolism
Gallium nitrate-MOA
inhibits osteoclasts
Plicamycin- MOA
inhibits osteoclasts
increases calcium excretion
decrease calcium excretion
Sevelamer- Use, MOA
Use: if pt has hyperphosphatemia
MOA: sequesters phosphate in food so cannot be absorbed
PTH increases calcium and phosphate intake in the ___
PTH decreases __ excretion and increases ___ excretion in the kidney.
PTh ___ calcium and phosphate release from bones
1. gut
2. calcium excretion is decreased
3. phosphate excretion is increased
4. increases
The PTH receptor is a ___ coupled membrane receptor and acts on the gut through ___
1. G protein coupled membrane
2. vitamin D
High levels of calcium will inhibit the secretion of ___ via calcium sensing receptors which are ___ in the parathyroid gland.
1. PTH
2. G protein coupled receptors
PTHs effect in the gut of increasing calcium absorption is mediated via ____. PTH stimulates the kidney portion of the activation of 1.
1. then allows increased calcium transport in the ___
1. vitamin D
2. gut
Activated vitamin D ___ PTH secretion and ___ the activation of more Vitamin D.
KIDNEYS are ESSENTIAL for operation of vitamin D loops
1. inhibits
2. inhibits
Estrogens- __ calcium release from bones thus estrogen replacement will help post menopausal women
1. decrease
Doxercalciferol- MOA
- similar to calcitriol, prodrug which is activated in the liver