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23 Cards in this Set
- Front
- Back
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The primary effect of diruetis is what?
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An increase in solute excretion, mainly Na+ salts. The increase in urine flow is secondary and is a response to the osmotic force of the additional solute within the tubule lumen.
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Drugs that increase the net urinary excretion of Na+ salts are called what?
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Natriuretics
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True or False:
No matter the salt intake, the kidneys adjust the excretion of Na+ and water to maintain the ECF volume within narrow limits. |
True
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Osmotic diuretics work where?
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Ostmotics work in the proximal tubule, descending loop of Henle, and the collecting duct
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What is the prototype diuretic?
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Mannitol
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How does an Osmotic diuretic work?
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*decreases sodium reabsorption by osmotic action
*increases medullary blood flow *washout of medullary tonicity |
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Where do Carbonic Anhydrase Inhibitors work?
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In the proximal tubule
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What is the prototype Carbonic Anyhdrase inhibitor?
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Acetazolamide (Diamox)
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How do Carbonic Anhydrase Inhibitors work?
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They inhibit carbonic anhydrase and increase bicarb excretion.
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Where do Thiazide diuretics work?
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In the distal convoluted tubule.
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What is the prototype for thiazide diuretics?
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HCTZ
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What is the mechanism for thiazide diuretics?
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They inhibit luminal co-transport (Na+ and Cl-)
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What is the prototype Type I Loop Diuretics?
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Ethacrynic Acid
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Where does a Type I Loop Diuretic work?
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in the ascending Loop of Henle
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How does a Type I Loop Diuretic work?
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It inhibits luminal cotransport (Na+, K+, 2 Cl-)
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What is the prototype Type II Loop Diuretic?
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Lasix (Furosemide)
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Where does Lasix work?
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Ascending loop of Henle
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What is the mechanism for any loop diuretic?
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It inhibits luminal cotransport (Na+, K+, 2 Cl-)
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What is diuretic that works in the cortical collecting tubule?
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Potassium sparing diuretics
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What are the prototypical K+ sparing diuretics?
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spironolactone and triamterene
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What is the mechanism for K+ sparing diuretics?
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The compete for aldosterone receptors. They inhibit luminal Na+ channels
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What is an expected effect of Diamox?
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Metabolic acidosis
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What is the most pressing concern during intubation?
electrolyte changes ekg changes positioning or airway management? |
airway management
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