Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
Describe effects of vacination of RVF for animals
|
Protection not always adequate
Can induce abortion and birth defects Farmers are resistant to vaccinating due to cost/side effects of vaccine |
|
|
Is there a vaccine for humans for RFV?
|
yes, but experimental, live attenuated
|
|
|
what are problems associated with RVF vaccine
|
poor case/control selectivity due to poor randomization
|
|
|
What is association of rains and RVF?
|
Usually "el nino" effect, but unpredictable when heavy rains will come.
|
|
|
What is genus of Crimean-Congo HF?
|
Nairovirus (family, bunyaviridae)
|
|
|
What is vector of Sandfly Fever Virus and where is it found?
|
Sandfly.
Found near Mediterranean, SWAsia. A related virus causes disease in S America |
|
|
What kind of disease does Sandfly fever produce
|
mild, febrile illness
|
|
|
where was cchf discovered and named?
|
first in Crimea and central asian republics in 44-47, then isolated in Congo in mid 50's.
|
|
|
what are primary vectors of CCHF
|
TICKS of genus Hyalomma
|
|
|
Geographic distribution
|
Africa, Balkans and W Asia
|
|
|
Transmission of CCHF
|
tick bite from Hyalomma
blood related exposures other exposures - crushing and lab |
|
|
describe transmission of CCHF via cattle/small mammals
|
ticks on small mammals, cattle eat small mammals.
|
|
|
What is incubation time with tick exposure vs infected fluids
|
4-12 with tick/2-7 from blood exposure
|
|
|
what are symptoms of CCHF
|
abrupt onset fever, chills, myalgia, severe headache
|
|
|
What are other possible symptoms of CCHF
|
GI, malaise, anoxeria
|
|
|
Describe hemorrhage in CCHF
|
profuse, massive hematomas and ecchymoses - lots of bleeding
|
|
|
What would we see in CCHF lab values
|
leukopenia, thrombocytopenia, hemoconcentration, proteinuria, elevated AST(liver enzymes)
|
|
|
What is mortality in CCHF?
|
HIGH - 15 - 40%
|
|
|
What can CCHF be mistaken for in early stages?
|
Malaria, in early stages similarities
|
|
|
What are some diagnostic symptoms that may be seen in CCHF
|
Bleeding eyes(vessels under clear membrane in eye), Bruising (ecchymosis), Capillary fragility, Rash, Eskar
|
|
|
CCHF lab confirmation time and lab tests?
|
PCR, early, transient viremia, antigen detection for approx 7 days
|
|
|
Treatment for CCHF?
|
Supportive
Mgmt of hemorrhage and DIC(replace and correct clotting abnormalities) IV ribavarin (not pg women) Hyperimmune serum? |
|
|
CCHF prevention?
|
avoid ticks!
DEET& permethrin clothing Removal of ticks with forceps |
|
|
is there a vaccine for CCHF?
|
in Bulgaria, a mouse brain vaccine.
IN agriculture, acaricide tx for animals and enclosures |
|
|
describe nosocomial and lab prevention of CCHF
|
Mask, gown, gloves of suspect cases.
lab needs to be alerted possible danger of aerosol |
