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68 Cards in this Set
- Front
- Back
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Where do members of Circoviridae replicate?
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in nucleus of dividing cells (ssDNA virus)
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Of the viruses studied thus far, which are enveloped?
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Herpesviruses
Retroviridae (except for A type) |
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Which viruses studied thus far have a ssDNA genome? Are they linear, segmented, or circular?
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Circoviridae (circular ssDNA)
Parvoviridae (linear non-segmented ssDNA) |
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Which viruses studied thus far does NOT have an icosohedral capsid?
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Poxviridae (brick shaped)
Retroviridae (rod-shaped) |
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Beak and Feather Disease virus is in which virus group?
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Circoviridae
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What is the infectious protein of Parvoviridae?
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VP2 (viral capsid protein 2)
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Which group do the Papillomaviruses belong to? What is their genome?
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Papoviridae
circular dsDNA |
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What virus causes Equine Sarcoids?
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BPV 1 and 2 (Bovine Papilloma Virus)
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Choose Alpha, Beta, or Gammaherpesvirinae...
...grows slowly |
Beta and gammaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirus...
...grows rapidly. |
Alphaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...latency in sensory neurons. |
Alphaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...contains the Cytomegaloviruses. |
Betaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...latency in kidneys, salivary glands, and lymphocytes. |
Betaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...latency in lymphoid cells. |
Gammaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...Lymphoproliferative disease associated. |
Gammaherpesvirinae
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Choose Alpha, Beta, or Gammaherpesvirinae...
...cell lysis does not occur until several days after infection. |
Betaherpesvirinae (probably Gamma too but I dunno)
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Choose Alpha, Beta, or Gammaherpesvirinae...
...EHV, BHV, pseudorabies. |
Alphaherpesvirus
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Choose Alpha, Beta, or Gammaherpesvirinae...
...malignant catarrhal fever |
Gammaherpesvirinae
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Where do Poxviruses replicate? What is their genome?
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Replicate in cytoplasm but dsDNA genome!
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What viral group is the Mareck's disease virus a part of?
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Alphaherpesvirinae
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These DNA viruses replicate in the cytoplasm.
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Poxviruses!
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What causes lumpyskin disease in cattle?
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Poxvirus
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What virus group causes Bovine Leukemia Virus?
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Retrovirus
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ORF is which type of virus?
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Parapoxvirus
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What is the genome of Retroviridae?
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+ssRNA
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What virus causes FMD? What group is this virus in?
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Aphtovirus is part of Picornaviridae
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Which viral groups have infectious genomes (that we've studied)?
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Caliciviridae
Picornaviridae |
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Which of the following two methods are frequently used to detect the presence of viruses?
EM and ELISA EM and HI (HI serum neutralization assay?) EM and virus isolation EM and PCR PCR and western blot |
EM and virus isolation
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Which of the following methods are frequently used to detect viral genome?
Virus isolation and FA (FA=fluorescence assay) FA and HA ELISA and PCR (ELISA is for Ag or Ab) Western blot and HI (western blot is for protein) PCR and RT-PCR |
PCR and RT-PCR
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Which of the following is the most frequent target in anti-viral drug development?
Binding and entry Genome integration DNA/RNA replication Egress |
DNA/RNA replication
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What is the difference between FPV and CPV
They have different morphology They are from different family They have different tissue tropism They are from different genus |
They have different tissue tropism
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Does the BHV-1 become latent in the trigeminal ganglion following a primary infection?
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yup
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What type of diseases are associated with herpes virus infections?
Up resp disease Abortion CNS disorder Ocular disease Hemorrhagic disease All of above |
all of the above
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What type of tissues do alphaherpes viruses infect?
Neuron Epithelium Liver Kidney Lung All of the above |
All of the above
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What types of dzs area ssociated with betaherpesvirinae
Chronic Inclusion body rhinitis Poor growth, Infectious mononucleosis/glandular fever-like syndrome |
Poor growth
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What types of dzs are associated with gammaherpesviruinae?
Chronic Lymphoproliferative dz Hemorrhagic Lymphoid tissue tumor |
hemorrhagic
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What is SN assay?
Examine the amount of virus Dilution assay for serum Serum neutralizing A serology test that measures the neutralizing antibody titer against a specific virus |
A serology test that measures the neutralizing antibody titer against a specific virus
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What does 1:64 stand for in SN test?
1 part serum neutralizing 64 part virus 1 part serum neutralizing the virus It is the serum dilution factor It means that serum at 1:64 dilution can still neutralizing 100% or 50% of 100 PFU or TCID50 infectious viruses |
It means that serum at 1:64 dilution can still neutralizing 100% or 50% of 100 PFU or TCID50 infectious viruses
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The Vx for Rabies require a SN at 1:5 for protection from rabies infection. Which of the following person is not safely protected from rabies?
The Missing Link has a titer at 1:5 Gallaxhar has a titer at 1:2 B.O.B has a titer at 1:10 Susan Murphy (Ginormica) has a titer at 1:200 |
galaxar has titer at 1:2
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What are common symptoms associated with poxvirus inection?
Diarrhea Skin lesions with papule, vesicle, pustule, scab Bronchitis Hepatitis |
Skin lesions with papule, vesicle, pustule, scab
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What are the unique features about the pox viridae?
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Big DNA virus, replicates in cytoplasm
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How does DNA tumor virus trigger transformation?
Turn on TXXN factor genes Express growth factor receptors Inactivate tumor-supressors Express growth factors |
Inactivate tumor-supressors
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What is the role of E7 in BPV?
Induce tumor via direct binding to p53 Induce tumor via direct binding to non-phos pRB Induce tumor via diret binding to phos pRB Induce tumore via activatining E2F, a cell cycle activator |
Induce tumor via direct binding to non-phos pRB
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How do RNA tumor viruses trigger transformation?
Inactivate the tumore repressor protein Express active form of growth factor receptor Express p53 Express pRB |
Express active form of growth factor receptor
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What is the oncogene from Marek's disease virus?
Large T Ag E1A and E2A E6 and E7 Viral telomerase |
Viral telomerase
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What is the morphology of Adenoviridae?
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Non-enveloped icosahedral with “spikes”
Spikes are penton fibers important in pathogenicity linear dsDNA |
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Where will the adenovirus replicate inside the cell?
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nucleus
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Does adenovirus have a very unique cellular receptor?
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nope; common in many viruses
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How many types of capsid proteins make up the virus capsid?
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3 types (VP1, 2, and 3)
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What are the 3 regions that the genome is functionally divided into?
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Early, late, and regulatory genes
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Is dermal layer permissive for Papovavirus infection?
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semi-permissive
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How do we define the types of Papillomaviruses?
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By their antigens (6 in cattle, 3 in dogs, 2 in rabbits, 100+ in humans)
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What is the difference between Equine Papillomavirus and Equine Sarcoid?
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Location of lesions
Papilloma: over muzzle and oral cavity, some genital tumors Sarcoid: over entire body |
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What is the age group with Equine Sarcoids?
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<6yrs (3-6)
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Canine Papillomaviruses usually _______________spontaneously and recovered dogs are _______________.
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Resolve spontaneously
Recovered dogs are immune |
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What happens during herpesvirus latency?
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gene is dormant; no virion
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Does virus express proteins during latency?
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YES; ONLY ONE! lat proteins
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What sample should you take from the sick animal if you suspect the animal has BHV-2 infection?
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Blood (for Ab development)
Sample the lesion |
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What is common feature of papillomavirus infection (papovavirus)
A. Cause acute diarrhea B. Cause URI C. Cause neurological dz D. Cause systemic infxn E. Cause benign tumor |
E. Cause benign tumor
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What is permissive tissue for papovavirus
A. Liver B. Brain C. Kermal layer of skin D. Keratinized layer of skin |
D. Keratinized layer of skin
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What is serum neutralization assay for?
A. Det of viral genome B. Det of virion C. Det of antibody D. Det of viral antigen |
C. Det of antibody
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What subfamilies of herpesviruses are possibly associated with tumor?
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gammaherpesvirus
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How does DNA tumor virus trigger transformation? (papillomavirus, most herpesvirus, adenovirus)
a. Turn on transcription factor genes b. Express GR receptors c. Inactivate tumor suppressors d. Express GFs |
c. Inactivate tumor suppressors
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2. What is the role of E7 in BPV?
a. Induce tumor via direct binding to p53 b. Induce tumor via direct binding to non-phosphorylated pRB c. Induce tumor via direct binding to phosphorylated pRB d. Induce tumor via activitaiton E2F, a cell cycle activator |
b. Induce tumor via direct binding to non-phosphorylated pRB
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3. How do RNA tumor viruses trigger transformation?
a. Inactivate the tumor repressor prto b. Express active form of GF receptor c. Express p53 d. Express pRB |
b. Express active form of GF receptor
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Which of the following replicates within the cytoplasm?
Infectious canine hepatitis virus Equine herpes type I virus Equine Papillomatosis virus Canine Distemper Swine Influenza virus |
Canine distemper
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Which one of the following replicates in the nucleus?
Bluetongue Bovine ephemeral fever virus Rabies virus Avian Influenza Bovine Parainfluenza virus 3 |
Avian influenza
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Which of the following has an infectious genome?
FeLV Canine Distemper Rabies Infectious canine hepatitis virus FIV |
Infectious canine hepatitis virus
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