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21 Cards in this Set
- Front
- Back
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If there are more immature neutrophils than normal, what is this called?
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"shift to the left"
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What is the fancy greek name for white cell?
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Leukocyte
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What are the two divisions of leukocytes? Give examples of each.
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Granulocytes (monocytes; dendritic cells)
Lymphocytes (B, T, and NK cells) |
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What is the major blood leukocyte in carnivores? What %?
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Neutrophils
60-75% |
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T or F:
Horses have more neutrophils (% basis) than ruminants. |
True!
Horses have 50% while ruminants have 20-30% |
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What is found in primary granules?
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Myeloperoxidase
Cathepsin B Elastase |
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What is found in secondary granules?
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Lysozyme
Collagenase lactoferase |
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What "sticky" proteins line blood vessels to facilitate neutrophil infiltration?
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Selectins and integrins
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T or F:
Selectins have weak interactions while integrins have strong interactions. |
True!
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What stimulates integrin and selectin expression?
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IL-1
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What is the process of neutrophil infiltration through the endothelium called?
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Diapedesis
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What are the four steps of phagocytosis?
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Chemotaxis (attracting)
Adherence (opsonization; make tastier) Ingestion Digestion |
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T or F:
The adherence stage of phagocytosis involves chemokines, opsonins, and antibodies. |
False!
It involves opsonins and antibodies but NOT chemokines. This is for chemotaxis. |
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What are the two types of digestion involved in phagocytosis?
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Respiratory burst
Lytic enzymes |
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What are two opsonins discussed in lecture?
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Antibodies
Complement |
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T or F:
Antimicrobial peptides are produced during respiratory burst. |
False bitch!
Oxidants do the burstin! |
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T or F:
Potent oxidants are produced during respiratory burst |
True!
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What is the character of the lytic enzymes produced during the digestion phase of phagocytosis?
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Antimicrobial peptides.
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T or F:
The respiratory burst pathway requires a ton of O2. |
Yup
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What are the "killer" molecules in the respiratory burst pathway?
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H2O2 and OCl-
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What two enzymes are necessary to make H2O2 in the respiratory burst pathway? What does each do?
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NOX (NADPH oxidase) turns O2 into O2-
SOD (superoxide dismutase) converts O2- into H2O2 |
