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9 Cards in this Set
- Front
- Back
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Fun facts
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Not typically in humans
Primarily a disease of cattles, goats and pigs |
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Mode of transmission
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Primarily a disease of cattles, goats and pigs
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Strains
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B. abortus (infects cattle)
B. melitensis (infects sheep and goats) B. suis (pigs) |
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Characteristics
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small, Gram-negative rods
Non-motile, non-acid fast, non-spore forming |
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Culture
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On broth or blood agar in aerobic condition w/ CO2***
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Clinical presentation
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Typical symptoms are NOT PRESENT
Reticuloendothelial organs are frequently affected - splenomegaly (MC), lymphadenopathy, hepatomegaly |
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Immunity
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Intracellular pathogens - multiply w/in macrophages by disrupting myeloperoxidase system, phagosome-lysosome fusion, monocyte cytokine production
Immunity mediated by T-helper cell and production of cytokines*** |
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Diagnosis
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Isolation
1:640 titers --> acute infection Lower titers --> previous infection or cross-reacting antibodies |
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Treatment
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DOC: Tetracycline and Doxycycline
Severe cases - Streptomycin, Gentamycin, or Rifampin is added |
