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46 Cards in this Set
- Front
- Back
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thiazides work where in the kidney
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distal convoluted tubule
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best diuretic for hypertension
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thiazides!
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for mild cardiac edema, cirrhotic or nephrotic edema and edema produced by hormone imbalance and meniere disease what do you do
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give thiazide andK sparing diuretic
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adverse effects of thiazide
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hypokalemia, hyponatremia, hypochloremic alkalosis
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what diuretic can lead to gout
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thiazide
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causes hyperglycemia, hypertriglyceridemia, hypercholesterolemia
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thiazides
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loops work where in kidney
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thick ascending limb of loop
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loops work on what transporter
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NKCC
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furosemide, piretanide, bumetanide, ethacrynic acid and torsemide
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loops
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treat CHF and reduce pulmonary edema
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loops ( often combined with thiazides)
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treat acute hypercalcemia and halide poisoning
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loops
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adverse effects of loops
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hypotension
volume depletion hypokalemia alkalosis Mg2+ wasting |
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ototoxicity
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loops and aminoglycosides
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K sparing drugs work at what site in the kidney
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distal part of collecting tubule
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K sparing drugs work at what receptor in kidney
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mineralcorticoid receptor
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eplerenone and spironolactone
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K sparing diuretics
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treat hypertension, CHF, refractory edema
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K sparing with loop or thizaide combo
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adverse effects of K sparing
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hyperkalemia, hyperchloremic metabolic acidosis, gynecomastia
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if pt has renal insuffiency due to diabetes or is taking an ACE inhibitor what do you not want to give them
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K sparing
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amiloride and triamterene
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K sparing version 2
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amiloride and triamterene work at what receptor
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ENaC
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amiloride and triamterene work where in the kidney
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cortical collecting duct
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triamterene or amiloride- what increases excretion of Mg?
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triamterene
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manage CHF, cirrhosis and edema cause by seondary hyperaldosteronism
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amiloride and triamterene
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causes hyperkalemia
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amiloride and triamterene and spironolactone and eplerenone
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carbonic anhydrase inhibitors work where in the kidney
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proximal tubule
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acetazolamide and methazolamide
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carbonic anhydrase inhibitors
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which diuretics are sulfonamide derivatives
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thizaides and carbonic anhydrase inhibitors
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used for glaucoma, seizures, acute mountain sickness
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carbonic anhydrase inhibitors
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alkinlize urine
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carbonic anhydrase inhibitors
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adverse reactions to carbonic anhydrase inhibitors
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metabolic acidosis, potassium wasting, renal stones
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contraindicated in cirrhosis
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carbonic anhydrase inhibitors
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osmotic agents
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mannitol, glycerin, urea, hypertonic saline
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how do osmotic agents work
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net reabsorption of Na is reduced and water is kept in lumen
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used for prophylaxis of acute renal failure from trauma or surgery
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mannitol
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used for corneal edema and opthalmic procedures
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glycerin
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treat diabetes insipidus
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central- vasopressin
renal- thiazide |
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nocturnal enuresis treatment
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desmopressin
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adverse effects to vasopressin-
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cardiac effects
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chlorpropamide, acetaminophen, indomethacin
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enhance ADH
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demeclocycline and lithium carbonate
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ADH antagonists
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treatment in SIADH
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demeclocycline and lithium carbonate- anti ADH
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probenecid MOA
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inhibits secretion of organic acids
at high doses it decreases resorptoin of uric acid by inhibiting URAT1 |
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probencid inhibits what drugs
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indomethacin and methotrexate
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allopurinol MOA
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inhibits xanthin oxidase prevents uric acid from being made
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used in treatment of gout
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probenecid and allopurinol
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