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16 Cards in this Set
- Front
- Back
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primary NT from postganglionic sympathetic neurons? how is it degraded in the presynaptic terminal?
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NE; MAO and COMT
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biosynthetic pathway from tyrosine to epinephrine
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tyrosine - L dopa - dopamine - norepinephrine - epinephrine
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VMA (vanillymandelic acid): what is it and when is its urinary secretion increased?
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metabolite of NE; in pheochromocytoma
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what NT is made from NE via the enzyme phenylethanolamine-N-methyltransferase
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epinephrine
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which NT is:
- prominent in midbrain - released from hypothalamus to inhibit prolactin secretion - metabolized by MAO and COMT |
dopamine
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receptor which activates adenylate cyclase via Gs protein
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D1
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receptor which inhibits adenyate cyclase via Gi protein
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D2
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Parkinson's disease
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degeneration of dopaminergic neurons that use D2 receptors
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Schizophrenia
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involves increased levels of D2 receptors
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NT which is:
- present in high conc. in brain stem - made from tryptophan - converted to melatonin in pineal gland |
serotonin
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NT which is
- made from histidine - present in neurons of hypothalamus |
histamine
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most prevalent excitatory NT in the brain; what receptor type does it have?
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glutamate; kainate receptor, which is an Na/K ion channel
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inhibitory NT made from glutamate by glutamate decarboxylase
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GABA
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receptor which is target of benzodiazepines and barbiturates; mxn of action?
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GABA(a) receptor; increases Cl- conductance at the site
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receptor to inhibitory NT which increases K+ conductance
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GABA(b)
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inhibitory NT found mostly in spinal cord and brain stem; mxn of action?
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glycine; increases Cl- conductance
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