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16 Cards in this Set

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primary NT from postganglionic sympathetic neurons? how is it degraded in the presynaptic terminal?
NE; MAO and COMT
biosynthetic pathway from tyrosine to epinephrine
tyrosine - L dopa - dopamine - norepinephrine - epinephrine
VMA (vanillymandelic acid): what is it and when is its urinary secretion increased?
metabolite of NE; in pheochromocytoma
what NT is made from NE via the enzyme phenylethanolamine-N-methyltransferase
epinephrine
which NT is:
- prominent in midbrain
- released from hypothalamus to inhibit prolactin secretion
- metabolized by MAO and COMT
dopamine
receptor which activates adenylate cyclase via Gs protein
D1
receptor which inhibits adenyate cyclase via Gi protein
D2
Parkinson's disease
degeneration of dopaminergic neurons that use D2 receptors
Schizophrenia
involves increased levels of D2 receptors
NT which is:
- present in high conc. in brain stem
- made from tryptophan
- converted to melatonin in pineal gland
serotonin
NT which is
- made from histidine
- present in neurons of hypothalamus
histamine
most prevalent excitatory NT in the brain; what receptor type does it have?
glutamate; kainate receptor, which is an Na/K ion channel
inhibitory NT made from glutamate by glutamate decarboxylase
GABA
receptor which is target of benzodiazepines and barbiturates; mxn of action?
GABA(a) receptor; increases Cl- conductance at the site
receptor to inhibitory NT which increases K+ conductance
GABA(b)
inhibitory NT found mostly in spinal cord and brain stem; mxn of action?
glycine; increases Cl- conductance