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5 Cards in this Set

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Describe the percentage composition of white blood cells
Granulocytes 50%-80% of WBC
Lymphocytes 20%-45% of WBC
Monocytes and Macrophages 3%-8% of WBC
Describe the steps in an immune response to pathogen
1. Processing of the foreign entity by a macrophage or B cell
2. Recognition of this foreign entity by specific, preformed receptors on certain B cells and T cells
3. Proliferation of these B cells and T cells as stimulated by soluble signals called interleukins between macrophages, B cells and T cells.
4. Blast transformation and a series of mitotic divisions leading to the generation from B cells of plasma cells that produce immunoglobins and from T cells of sensitized T cells - all capable of interacting with the original foreign stimulus.
What is an epitope?
An epitope is the restricted portion of an antigen molecule that determines the specificity of the reaction with an antibody

is the antibody-binding site on an antigen for a specific antibody

generally contains 4 to 6 aa or sugar residues
What is a Hapten?
A Hapten is a small foreign molecule that is not immunogenic by itself but can bind to an antibody molecule already formed to it.

Hapten can be immunogenic if coupled to a sufficiently large carrier molecule.
At what amino acid positions can the variable domains be found?
25-35, 50-58 and 95-108