Brs Immuno

Front 1

Describe the percentage composition of white blood cells

Back 1

Granulocytes 50%-80% of WBC
Lymphocytes 20%-45% of WBC
Monocytes and Macrophages 3%-8% of WBC

Front 2

Describe the steps in an immune response to pathogen

Back 2

1. Processing of the foreign entity by a macrophage or B cell
2. Recognition of this foreign entity by specific, preformed receptors on certain B cells and T cells
3. Proliferation of these B cells and T cells as stimulated by soluble signals called interleukins between macrophages, B cells and T cells.
4. Blast transformation and a series of mitotic divisions leading to the generation from B cells of plasma cells that produce immunoglobins and from T cells of sensitized T cells - all capable of interacting with the original foreign stimulus.

Front 3

What is an epitope?

Back 3

An epitope is the restricted portion of an antigen molecule that determines the specificity of the reaction with an antibody

is the antibody-binding site on an antigen for a specific antibody

generally contains 4 to 6 aa or sugar residues

Front 4

What is a Hapten?

Back 4

A Hapten is a small foreign molecule that is not immunogenic by itself but can bind to an antibody molecule already formed to it.

Hapten can be immunogenic if coupled to a sufficiently large carrier molecule.

Front 5

At what amino acid positions can the variable domains be found?

Back 5

25-35, 50-58 and 95-108