Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
Unique characteristic of asthma compared to others? |
Reversible in nature. |
|
|
Types of asthma. |
Extrinsic:- Type I HR, ext. Ag (house dust containing mite & pollen), ⬆️IgE, childhood, H/O atopy. Intrinsic:- adult. Viral inf., Drugs( NAIDS), Cold. |
|
|
On taking pain killers, why asthemic patients still have broncospasm? |
AA---COX( inhibited by painkillers)-PG AA--- LOX- LTs- bs. |
|
|
Notorious drug which can cause asthma attack? |
NSAIDS----- Aspirin. These people have a SAMTER'S tried:- a. Aspirin intolerance b. Asthma c. Adult nasal polyps. |
|
|
Nasal polyp history. |
Adult- any of SAMTER'S tried. Child- cystic fibrosis. |
|
|
Cp of asthma. |
Dyspnoea, wheezing, nocturnal cough--indicate extrinsic asthma. |
|
|
Diagnosis of asthma. |
1.spirometry. 2. Sputum examination 3. "Airway Remodeling". |
|
|
Characteristic of asthemic sputum. |
{curschman spirals- airway of epi. getting detached n form zig zag b/c of air trapping in b/w.charcot- Leyden crystal- (GALACTIN 10).creola bodies- degenerated epi. cells} |
|
|
Airway Remodeling. |
AL- SBM- more deposition of collagen in bm. E- presence of eosinophils+ mucus glands. SM- more thick, ⬆️ in no. n size. |
|
|
Increase smooth muscle qualification is assisted by activity of which gene? |
ADAM 33 gene.----SM+ fibroblast. |
|
|
Severity of asthma. |
YKL 40 protein If concentration of ykl-40 protein is higher then person is having more severe asthma. |
|
|
Rx in asthma. |
1. Salbutamol, terbutaline, salmeterol, formeterol.....bronchodilators. 2. Steroids...to reduce inflammation. 3. Montelukast. |
