Breast/colon Cancer -Blanch

Front 1

mendilan mut

Back 1

DOM, bilateral, early onset

Front 2

sporadic mut

Back 2

reccessive, unilateral, late onset

Front 3

breast cancer-stats

Back 3

1-12
1-3 (if someone has it under 40 in fam)
5-10% is single gene

Front 4

DCIS

Back 4

High risk for breast cancer if untreated)

non-invasive (unless u dont treat)

Front 5

LCIS

Back 5

pre-cancerous
risk for bilateral b-cancer

Front 6

BRCA1 and BRCA2
-what kind of cancer
%'s

Back 6

Hereditary Breast Ovarian

50% of herditary b-cancer
90% of familiar segregaton

Front 7

TP53

Back 7

Li-Fraumeni Syndrome

Front 8

PTEN

Back 8

Cowden Syndrome

papllia around mouf

Front 9

Peutz Jeghers Syndrome-gene

Back 9

STK11

Front 10

Bilateral breast cancer is a slight predictor for

same with male b-cancer

Back 10

BRCA1 and BRCA2 mutations

Front 11

Chrome for BRCA1

Back 11

17

Front 12

Chome for BRAC2

Back 12

13

Front 13

Men b-cancer?

Back 13

BRAC2

Front 14

Biallelic mutations of BRCA2 gene
casue what type of anemia

Back 14

Fanconi Anemia (FA)

Microcephaly, congenital heart disease
Aplastic anemia (Bone marrow fails to produce blood cells including red an white as well as platelets)

LOCUS hertogenity

Front 15

Gene test results (Positive)

Back 15

you def got that shit

Front 16

Gene test results (Variant of uncertain significance
)

Back 16

got some missense...dont know if its one of the problems

Front 17

Gene test (negative-Known family istory)

Back 17

TRUE negative (but your chances dont go to zero)

Front 18

Gene test (negative-unknown family istory)

Back 18

Mutation unknown within the family – this results is considered as an uninformative result, remember the testing does not detect 100% of mutations

Front 19

colon rectal cancer-stats

Back 19

3rd most common w/ men

Front 20

RF for CRC

Back 20

adenomas - beign tumors
High-fat, low-fiber diet
Aging

Front 21

FAP

Back 21

1%
more then 100 polyps
AD

Front 22

FAP gene

Back 22

APC
5q chrom

Front 23

FAP - polyps

Back 23

w/ 100 polyps
90% penetrances

Upper GI probs too

untreatd poly 100% cancer

Front 24

HPNCC - LYNCH syndrome

Back 24

5%
early onset 20's
FEW POLYPS
right side colon damage

Front 25

HPNCC - GENE

Back 25

MMR - mismatch repair

or

TSG's
MSH2, MLH1, MSH6, PMS2

Front 26

microsat check for which disorder

Back 26

HPNCC
95% multiple loci

Front 27

Peutz-Jeghers syndrome (PJS)

Back 27

Hamartomatous (benign tumor like) polyps of GI tract as early as 1st decade

small intestines

Mucocutaneous hyperpigmentation - on lips