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9 Cards in this Set
- Front
- Back
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Ductal Carcinoma In Situ
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Non-invasive, non-palpable
Cribiform (sieve-like), comedo (necrotic center), microcalcifications (only way to see on mammogram) 1/3 will eventually invade Tx: lumpectomy |
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Lobular carcinoma in situ
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Non-invasive, non-palpable, cannot be identified on mammogram (almost always an incidental finding)
Lobules distended, 1/3 eventually invasive Increased incidence of cancer in other breast |
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Infiltrating ductal carcinoma
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Invasive, stellate, indurated (reactive fibrosis), grey-white
1/3 have amplification of ERBB2 (poor prognosis) |
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Paget's disease of the nipple
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Extension of DCIS, produces rash w or w/o nipple retraction. Paget's cells
Palpable mass usually present (always underlying cancer) |
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Medullary Carcinoma
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A/w BRCA1
Bulky, soft, large cells w lymphoid infiltrate Majority are estrogen and progesterone receptor negative |
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Inflammatory Carcinoma
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Erythematous breast with dimpling like an orange
Plugs of tumor blocking lumen of dermal lymphatics (localized lymphedema), poor prognosis |
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Invasive lobular carcinoma
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Neoplastic cells arranged in linear fashion or form concentric circles
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Tubular Carcinoma
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Develops in terminal ductules, increased incidence of cancer in opposite breast
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Colloid (mucinous) carcinoma)
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Usually occurs in elderly, neoplastic cells surrounded by mucin
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