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10 Cards in this Set
- Front
- Back
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Describe what is seen in acute neuronal injury.
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Red neurons
body shrinks nisl disappears pyknotic nucleus absent nucleolus |
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When is neuronal atrophy/ degeneration seen?
What takes place during neuronal atrophy/degeneration? |
progressive neurologic disease
neoronal cell loss and reactive gliosis |
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What can be seen in the cell body pathologically when an axon is injured
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cell body changes:
disersed nissl substance enlargement peripheral nucleus with enlarged nucleolus and a central neuronal cell body |
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What are neuronal inclusions?
Cause? Location? Composition? |
Nueronal inclusions are substances visable in neurons that are not normally seen
aging, infection, degenerative/metabolic diseases intranuclear cytplasmic axonal viral particles, proteins, etc. |
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What is seen in lipofuscin neuronal inclusions?
When is it seen? |
intracytoplasmic lysosomal accumulation of orange-brown granules
complex lipids/lipoproteins often seen in aging |
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What is seen in spheroid neuronal inclusions?
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eosinophillic axonal swellings
neurofilaments, organelles, transport material accumulates focally when axon is damaged |
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What is seen in lewy bodies?
What disease causes these? |
hylaine eosinophillic cores with pale halos
cytoplasmic inclusions (cytoskeletal proteins) seen in parkinsons |
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What is seen in neurons with cytomegalovirus?
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eosinophillic intranuclear inclusions
CMV viral particles |
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What is seen in Tay Sachs Ganglioside neurons?
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PAS positive gaglioside storage granules
accumulate in teh cytoplasm of neurons |
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What are the glial reactions involving astrocytes?
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Cellular swelling due to acute insult (hypoxia)
fibriallary gliosis (nospecific reation to injury) Cavitation (end result of CNS injury) Alzheimer type 2 astrocytes astrocytic inclusions (rosenthal fibers) corpora amylacea (degenerative change) |
