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4 Cards in this Set

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Daily ATP Useage

100-150 ATP moles used by cells daily




150 ATP moles = 9 x 10^25 molecules




50-75kg ATP needed in a single day




Each ADP molecule is recycled 1000-1500 times daily




The brain consumes most of this

Human Brain

Glucose is the main energy source




This links with brains high oxygen comsumption




2% of body weight


15% blood supply


20% oxygen consumption


25% glucose




Most energy demanding organ in nature




Consumption is out of proportion to size




High maintenance = vulnerable




No other organ is as sensitive to energy loss

Where is ATP Used in the Brain

High energy processes in the neurones


-Active K+ transport


-Glutamate signalling

Glutamate Signalling

Enzyme Na+K+ATPase is an ATP synthase in reverse gear




Glutamate mediates most of the excitatory signalling in human brain




It opens cation channels thus activating post-synaptic membrane