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16 Cards in this Set
- Front
- Back
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what type of receptor does nicotine act at? |
binds to and initially stimulates nicotinic AcH receptors |
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Briefly describe nicotines biphasic effect |
remains attached to these receptors, effectively blocking further activation & resulting in longer calming effect |
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What 2 transmitters systems do these drugs primarily interact with Amphetamine & Cocaine |
DA & NE |
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How does cocaine interact with these transmitters (same as) which stage of cycle? |
cocaine blocks the reuptake of transmitters
upregulates DA & NE activity by bloackage of cathecholomine reuptake following normal tranmitter release |
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What transmitter does LSD structually resemble |
seratonin |
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what is the mechanism of action of LSD |
binds to and activates the seratonin receptor, upregulates seratonin activity |
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Barbiturates, Benzodiazepines, Alcohol
which transmitters do all these CNS depressents interact with |
GABA |
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what is an additional mechanism of action of ethanol which is not transmitter specific |
inhibits flow of NA+ across the neurolema; high concentration of ETOH can damage neurolema & interfere with transmission of action potential |
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What are two examples of opiate narcotic drugs |
heroin, methadone, morphin |
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all opiate narcotics interact at receptors for which endegenous substances (natural) |
endorphins & enkephalins |
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What is the mechanism of action of marijuana |
binds to specific cannabinoid receptors in the CNS |
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name our endegenous (naturally occuring) marijuana-like substance |
anandamide |
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what two transmitter system does XTC interact with |
low doses increases the release of dopamine
higher dose seratonin |
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what transmitter system does PCP interact with |
glutamic acid receptors |
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what are the two mechanism of action of caffeine |
metabolizes cAMP blocks adenosine to inhibit glutamide release |
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what blocks phosphodiesterase |
caffeine |
