Botanicals - Chronic Stress

Front 1

Adaptogens - mechanism

Back 1

Increase ACTH/cortisol -> normalize w/long term use -> stimulate HPA axis (neg feedback) -> restore circadian rhythm

Front 2

What stage of stress are adaptogens stimulating?

Back 2

Level 3 - severe/exhaustive stress

Front 3

Siberian Ginseng is from what family?

Back 3

Araliaceae

Front 4

Endocrine function of Siberian Ginseng

Back 4

1) reduces adrenal hypertrophy

2) decreases corticosteroid and glucose production

3) prevents/delays exhaustive stress

Front 5

Siberian Ginseng increases what form of lymphocytes?

Back 5

CD4 T- lymphocytes

Front 6

Role of COMT and Siberian Ginseng

Back 6

1) inhibits COMT

2) centrally = HPA -> negative feedback -> decreases cortisol

3) peripherally = counters resistance to prolonged hypercortisolemia -> increases activity

Front 7

Plant name: Siberian Ginseng

Back 7

Eleutherococcus senticosus

Front 8

Siberian Ginseng and QoL

Back 8

1) n= 20

2) findings of improved QoL did not persist at 8 weeks

3) lower than normal dosing

Front 9

Siberian Ginseng and Stress

Back 9

1) n = 144

2) no difference between ginseng and management class

2) lower than normal dose

Front 10

Siberian Ginseng and Chronic Fatigue

Back 10

1) n = 76

2) adequate dosing with 500 mg q6hours

3) decreased fatigue in lower fatigued people

4) no decrease in fatigue in high level fatigued people

Front 11

Siberian Ginseng and Indurance

Back 11

1) n = 9

2) Improved endurance at 8 weeks

Front 12

Siberian Ginseng and Metabolic Syndromes

Back 12

Siberian vs. American vs. Fiber

1) decrease glucose levels (fasting and post prandial) = Siberian > American > Fiber

2) Siberian decreased A1C, TG, and cholesterol

Front 13

Siberian Ginseng and HSV2

Back 13

1) n =93

2) decreased outbreaks by 50% at 6 months

3) decreased severity and duration of outbreaks

Front 14

Plant name for American Ginseng

Back 14

Panax quinquefolius

Front 15

T/F Eleutherococcus reduces severity of common cold

Back 15

True

Front 16

What combination with Eleutherococcus reduces osteoarthritic knee pain?

Back 16

Eleutherococcus + Panax notoginseng + Rehmannia glutinosa

Front 17

What combination with Eleutherococcus improved attention speed, and accuracy?

Back 17

Eleutherococcus + Rhodiola rosea + Schisandra chinensis

Front 18

Eleutherococcus Interactions

Back 18

1) rare urticaria

2) increased risk of bleeding (use caution with anticoagulants)

3) may counteract immunosuppressants

Front 19

Which CYP can Eleutherococcus potentially inhibit?

Back 19

CYP1A2 and CYP2C9

Front 20

What is the plant name for Ashwagandha?

Back 20

Withania somnifera

Front 21

What family does Ashwagandha belong to?

Back 21

Solanaceae

Front 22

What does Ashwangandha do?

Back 22

1) stimulates weight gain

2) increases cell counts

3) supports recovery from iron deficiency anemia

4) reduces inflammation

Front 23

Withania and Chronic Stress

Back 23

1) n =64

2) decreased stress and cortisol versus placebo

3) 8 weeks

Front 24

Withania and Neurologic effects

Back 24

1) n = 60

2) no change in mood and anxiety in bipolar disorder

3) Improves anxiety in non bipolar disorder

Front 25

What did Withania improve in patients with bipolar disorder?

Back 25

1) social cognition

2) working memory

3) reaction time

Front 26

T/F: Withania somnifera contains alkaloids.

Back 26

True

Front 27

Function of withania alkaloids

Back 27

1) smooth muscle spasmolytic

2) high doses: GABA A receptor stimulation (hypotension, bradycardia, cerebral depressant)

Front 28

T/F: Rhodiola increases mental and physical fatigue.

Back 28

False

Front 29

Rhodiola and Endurance

Back 29

1) improved endurance

2) decreased perception of effort

Front 30

Rhodioloa and Stress

Back 30

Improvement in feelings of:

1) stress

2) disability from stress

3) overall wellness

Front 31

What herbal lowers feelings of stress and depression?

Back 31

Rhodiola

Front 32

T/F: Rhodiola is best with level 1 stress.

Back 32

False - level 3

Front 33

Adverse reaction: Rhodiola

Back 33

dry mouth

Front 34

What are the three ginsengs?

Back 34

1) Panax - Chinese Ginseng

2) American Ginseng

3) Siberian Ginseng

Front 35

What are the benefits of Panax Ginseng?

Back 35

Best for debilitated patients

Front 36

What is the best patient population for American Ginseng?

Back 36

1) Mild/Moderate fatigue

2) Issues with cognition

Front 37

What is the best population for Siberian Ginseng?

Back 37

1) Improve endurance

2) long term stamina in stress

3) improve circadian rhythm