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95 Cards in this Set

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HLA B27
PAIR

Psoriasis
Ankylosing spondylitis
Inflammatory bowel disease
Reiter's Syndrome
HLA B8
Grave's disease
Celiac sprue
HLA DR2
Multiple sclerosis
hay fever
SLE
Goodpasture's
HLA DR3
DM type I
HLA DR4
DM type I
Rheumatoid arthritis
HLA DR5
Pernicious anemia
Hashimoto's
HLA DR7
Steroid-response nephrotic syndrome
Antinuclear antibodies
seen with SLE
Anti-dsDNA and anti-Smith antibodies
specific for SLE
Antihistone antibodies
Drug-induced lupus
Anti-IgG antibodies
Rheumatoid arthritis
C-ANCA, P-ANCA (antineutrophil antibodies)
vasculitis
Anticentromere antibodies
scleroderma (CREST)
Anti-Scl-70 antibodies
Scleroderma (diffuse)
Antimitochondrial antibodies
primary biliary cirrhosis
Antigliadin antibodies
celiac disease
Anti-basement membrane antibodies
Goodpasture's syndrome
Anti-epithelial antibodies
Pemphigus vulgaris
Antimicrosomal antibodies
Hashimoto's
Anti-Jo-1 antibodies
Polymyositis
Dermatomyositis
umbilical vein derivative
ligamentum teres hepatis
umbilical arteries derivatives
medial umbilical ligaments
allantois
urachus -> median umbilical ligament
notochord
nucleus pulposus of intervertebral disk
first part of aortic arch derivative
maxillary artery
Second part of aortic arch derivative
stapedial artery
third part of aortic arch derivative
common carotid artery and proximal part of internal carotid artery
4th part of aortic arch derivative
aortic arch on left

proximal part of subclavian artery and right

(4th part = 4 limbs = systemic)
sixth part of aortic arch derivative
proximal part of pulmonary arteries and ductus arteriosus

(pulmonary and pulmonary-systemic shunt)
Branchial arch 1 derivatives
Mandible, Meckel's cartilage, Muscles of Mastication, Masseter, lateral and Medial pterygoid

feeling on ant. 2/3 of tongue

Maxillary and mandibular branches of trigeminal
Branchial arch 2 derivatives
Stapes, Styloid process, stylohyoid ligament, Stapedius, muscles of facial expression, Stylohyoid, post belly of digastric

Facial nerve
Branchial arch 3 derivatives
Greater horn of hyoid

stylopharyngeus

glossopharyngeal nerve
Branchial arch 4-6 derivatives
thyroid cartilages

4th: pharyngeal constrictors, CRICOTHYROID, levator veli palatini..... Superior laryngeal branch

6th: all intrinsic muscles of larynx except the cricothyroid.... recurrent laryngeal branch
Branchial cleft derivatives
1st: external acoustic meatus

2-4: cervical sinuses (thyroglossal duct cyst)
Ear development from the 1st arch
Malleus/incus

Tensor Tympani
Ear development from the 2nd arch
Stapes

Stapedius
1st Branchial Pouch derivative
middle ear cavity
eustachian tube
mastoid air cells
2nd Branchial Pouch derivative
epithelial lining of palatine tonsil
3rd Branchial Pouch derivative
inferior parathyroids

thymus

(DiGeorge)
4th Branchial Pouch derivative
superior parathyroids
Cleft lip
failure of fusion of maxillary and medial nasal processes
Cleft palate
failure of fusion of the lateral palatine processes, the nasal septum, and/or the median palatine process
Diaphragm derived from:
Several Parts Build Diaphragm

Septum transversum
Pleuroperitoneal folds
Body wall
Dorsal mesentery of esophagus
Innervation of the Diaphragm
C3-4-5 keeps the diaphragm alive
Pancreas embryology, Ventral head
from foregut

becomes the pancreatic head, uncinate process, and main pancreatic duct
Pancreas embryology, Dorsal head
from foregut

becomes body, tail, isthmus, and accessory duct
Spleen embryology
arises from dorsal mesentery but supplied from artery from foregut
Annular pancreas
ventral and dorsal pancreatic buds abnormally encircle the duodenum
- according to Kaplan, ventral wraps around the 2nd part of the duodenum
Disease associations with neoplasms, Down's Syndrome
ALL (we all fall down)
AML
Disease associations with neoplasms, gastritis/pernicious anemia
Gastric adenocarcinoma
Disease associations with neoplasms, tuberous sclerosis
astrocytoma and cardiac rhabdomyosarcoma
Disease associations with neoplasms, Plummer-Vinson syndrome
squamous cell carcinoma of the esophagus
Disease associations with neoplasms, Cirrhosis
hepatocellular carcinoma
Disease associations with neoplasms, ulcerative colitis
Colonic adenocarcinoma
Disease associations with neoplasms, Paget's disease of the bone
secondary ostersarcoma and fibrosarcoma
Disease associations with neoplasms, Immunodeficiency states
malignant lymphoma
Disease associations with neoplasms, Autoimmune diseases
benign and malignant thymomas
Disease associations with neoplasms, acanthosis nigricans
visceral malignancy
Disease associations with neoplasms, dysplastic nevus
malignant melanoma
abl mutation associated with
CML

Gain of function, only need to damage one allele
c-myc mutation associated with
Burkitt's lymphoma

Gain of function, only need to damage one allele
bcl-2 mutation associated with
Follicular and undifferentiated lymphomas

Gain of function, only need to damage one allele
erb-B2 mutation associated with
Breast, ovarian, and gastric carcinomas

Gain of function, only need to damage one allele
ras mutation associated with
Colon carcinoma

Gain of function, only need to damage one allele
L-myc mutation associated with
Lung tumor

Gain of function, only need to damage one allele
N-myc mutation associated with
Neuroblastoma

Gain of function, only need to damage one allele
ret mutation associated with
ret

Gain of function, only need to damage one allele
Rb mutation associated with
osteosarcoma and retinoblastoma

on 13q chromosome

Loss of function requires mutation on both alleles
BRCA 1/2 mutation associated with
breast and ovarian cancer

on 17q/13q chromosomes

Loss of function requires mutation on both alleles
p53 mutation associated with
Most human cancers, Li-Fraumeni syndrome

on 17p chromosome

Loss of function requires mutation on both alleles
p16 mutation associated with
Melanoma

on 9p chromosome

Loss of function requires mutation on both alleles
APC mutation associated with
Colorectal cancer

on 5q chromosome

Loss of function requires mutation on both alleles
WT1 mutation associated with
Wilm's tumor

on 11q chromosome

Loss of function requires mutation on both alleles
NF1 mutation associated with
Neurofibromatosis type 1

on 17q chromosome

Loss of function requires mutation on both alleles
NF2 mutation associated with
Neurofibromatosis type 2

on 22q chromosome

Loss of function requires mutation on both alleles
DPC mutation associated with
Pancreatic cancer

on 18q chromosome

Loss of function requires mutation on both alleles
DCC mutation associated with
Colon cancer

on 18 q chromosome

Loss of function requires mutation on both alleles
CA-125 marker for
Ovarian, malignant epithelial tumors
S-100 marker for
Melanoma, neural tumors, astrocytomas
Bombesin marker for
Neuroblastoma, lung and gastric cancers
TRAP marker for
Hairy cell leukemia
CA-19-9 marker for
Pancreatic adenocarcinoma
Nitrosamines as carcinogen
esophagus, stomach
Arsenic as carcinogen
skin (SCC)
Naphthalene dyes as carcinogens
bladder (transitional cell)
Alkylating agents as carcinogens
leukemias
Paraneoplastic effects of Small cell lung carcinoma
ACTH -> Cushing's
Paraneoplastic effects of Small cell lung carcinoma and intracranial neoplasms
ADH -> SIADH
Paraneoplastic effects of Squamous cell lung carcinoma, breast carcinoma, multiple myeloma, and bone metastasis
PTH-related peptide, TGF-B, TNF-a, IL-1
Paraneoplastic effects of Renal cell carcinoma and hemaangioblastomas
Erthyropoietin -> polycythemia
Paraneoplastic effects of thymoma and small cell lung carcinoma
Abs against presynaptic Ca channels at NMJ -> Lambert-Eaton syndrome (muscle weakness)
Paraneoplastic effects of Leukemias and lymphomas
Hyperuricemia from excess nucleotide turnover -> gout, urate nephropathy
Tumors that metastasis to the brain
Lung, Breat, Skin, Kidney, GI

"Lots of Bad Stuff Kills Glia"
Tumors that metastasis to the liver
more common than primary liver tumors

Colon > Stomach > Pancreas > Breast > Lung

"Cancer Sometimes Penetrates Benign Liver"
Tumors that metastasis to the bone
Prostate (blastic), Thyroid, Testes, Breast (both lytic and blastic), Lung (lytic), Kidney

"P.T. Barnum Loves Kids"

more common than primary bone tumors