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12 Cards in this Set
- Front
- Back
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Bordetella pertussis , what does it look like?
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gram (-) small rods, STRICT aerobes! ; encapsulated organism
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reservoir of pertussis? transmission?
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human vaccinated ; respiratory droplets
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pathogensis of b.pertussis?
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- mucosal surface pathogen
- attaches to nasopharyngeal epithelial cells --> hemagglutinin; pertussis toxin - toxins --> destroy resp. epthlium - adenylate cyclase toxin impairs leukocyte cheomtaxis - pertussis toxin--> (A/B toxin) --> causes ADP ribosylation of Gi (which inhibits negative regulator of AC) --> prevents cell surface signalling |
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Pertussis toxin causes what to happen in the cell?
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lymphocytosis promotion, islet activation --> hypoglycemia, blcoks immune effector cells and INCREASES histamine activity
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what diseases does Pertussis cause? What are the 3 phases?
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Whooping cough: phases happen after a 7-10 day incubation
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phase 1...
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1-2 weeks, CATARRHAL phase --> rhinorrhea, malaise, fever, sneezing and is CONTAGIOUS
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phase 2...
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2-4 weeks after initiation of disease--> repetitive WHOOP COUGHs, vomiting and anoxia; severe cough can cause --> neurological/ eye damage (hemorrhages)
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phase 3...
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>3 weeks convalescence --> less cough, complications then manifest --> pneumonia, seizures and encephalopathy
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what is the differential for whooping cough?
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- c.pneumo
- m.pneumo -rsv -adenovirus |
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diagnosis of whooping cough?
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- Regan-Lowe or Bordet-Gengou media from cough plates or nasopharyngeal cultures
- DFA (direct immunofluorescence) |
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Treatment for pertussis is...
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supportive
- hospitilization if less than 6 moa - erythromycin for 14 days (including all household contacts) - give macrolides too |
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how do you prevent pertussis?
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- vaccine--> dTAP --> immunity wanes in 5-7 years
- babies are often born w/ little or no immunity from the mother (IgA) |
