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7 Cards in this Set
- Front
- Back
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Bordatella is the cause of what? |
whooping cough |
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list the virulence factors/toxins |
pertussis toxin- ribosylates Gi - disabling it. This causes an increase in cAMP. [disabled GI soldier with a BOW and tents in the background] - ADP ribosylation also disables chemokine receptors for lymphocytes making them unable to enter lymphoid tissue so they get stuck in the bloodstream causing massive lymphocytosis. [popcorn kernels] Adenylate cyclase toxin: acts like edema factor from bacillus anthracis/ an adenlyate cyclase that also increases cAMP Tracheal toxin: part of the peptidoglycan wall of pertussis, and damages ciliated cells in the respiratory epithelium [tracheal tracter plows long blades of gras like the ciliated epithelium of the resp. tract. |
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How does it infect people? |
Transmitted via respiratory droplets, attaches to the respiratory epithelium using pili called filamentous hemagglutinin. Once attached, rather than invading, it releases toxins that cause these systemic effects. |
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Antibodies against what help protect against infection? |
filamentous hemagglutinin (the pilus that attaches to resp epithelium). [streamers] |
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Clinical findings for bordatella pertussis infection? |
initially presents with non-specific symptoms - called the catarrhal phase. Lasts about 1-2 weeks. Usually presents with conjunctival injection and lacrimation. Paroxysmal stage- cal last for 2 weeks or 2 months. Patients develop characteristic cough. Usually happens in kids. Intense bout of coughing that gets the child so out of breath, that when he does breathe in, it makes this characteristic whooping sound on inspiration. [air horn] Convalescent stage - can last for up to 3 months. gradual reduction of symptoms "hundred day cough" |
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Treatment? |
macrolides. Start early! |
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Prevention: |
two vaccines: first is killed, but we dont use it in the US anymore. 2nd is acellular vaccine composed of purified antigens of the bacteria. Usually given to kids along with hte diptheria and tetanus toxoids. DTaP. |
