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7 Cards in this Set
- Front
- Back
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How do Beta Blockers work to decrease BP?
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decrease activation of B1 receptors on the heart - results in decrease cardiac output. Decreases amount of work done by the heart - good for CHF
Also serve to decrease renin production (B1 receptors on JG cells). Decrease PVR and decrease aldosterone (Na, H2O) |
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What are calcium channel blockers used for?
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Diastolic HPTN is the major use
diltiazem - vasculature and heart nifedipine - vasculature verapmil - heart and vasculature Block the ability of calcium to enter the cell - decreased contraction force. vasculature - VD, decreased BP |
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What is the first line drug used for HPTN in pts with chronic renal dx or diabetes mellitus?
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1st - ACE inhibitor or ARB - renal protective
for everything else - thiazide is the DOC |
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What is the DOC for a patient with a Hx of angina or MI and has HPTN?
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get the BP to <130/80 and use a beta-blocker AND either an ACE inhibitor or and ARB. ADD a CCB or thiazide if unsuccessful
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What is the MOA of ARBs?
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angiotension 2 receptor antagonists. Similar to ACE inhibitor however they do not increase levels of bradykinin (VD)
no cough associated like ACE Less BP drop than ACE |
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What are ergot alkaloids used for?
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treatment and prophylaxis of moderate to severe migraines - ergotamine - cause VC
prophylaxis of migraines - methysergide |
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What is Cyproheptadine used for?
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cluster headaches and occasionally in prevention of migraine - blocks 5-HT2 receptors
Triptans are better though |
