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7 Cards in this Set
- Front
- Back
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How do Thiazides work?
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antihypertensive agent
block sodium uptake in the DCT - results in increased sodium excretion. Reducing blood volume and then decreasing cardiac output hypokalemia, hypercalcemia, hyperuricemia Hydrochlorothiazide |
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How do ACE inhibitors work?
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inhibit the conversion of angiotension 1 to 2. Decreased angiotension 2 causes increased vasodilation and decreased water and sodium retention. Also, increased bradykinin activity augments the decrease in BP.
dry cough, rash, fever, altered taste, HPoTN, hyperkalemia, angiedema, 1st dose syncope -pril |
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Should you ever give nitroprusside orally?
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NOOOOOO
it is poisonous if given orally because of its hydrolysis to cyanide It is given IV |
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What is HPTN emergency and what is used to treat it?
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>210/150 BP
must be dropped quickly before end stage organ damage. IV nitroprusside - VD arteries and veins - decreases preload diazoxide - direct arteriolar vasodilator labetalol - beta/alpha blocker |
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What is the MOA of spirnolactone?
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aldosterone antagonist, blocking the effects of aldosterone. Prevents uptake of sodium and water at the DCT and CD of the kidney.
With sodium not reabsorbed, Potassium is retained in the body. Causes hyperkalemia, met acid |
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What is sumatriptan?
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5-HT1 agonist
more powerful anti-migraine than ergot alkaloids. Useful in prevention and treatment of migraines avoid using in SSRI, SNRI, and MAOI because of serotonin syndrome |
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What serotonin meds are used for anti-emetic?
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Ondansetron, granisetron, dolasetron, palonosetron - 5HT3 antagonists -
metoclopramide - 5-HT4 - increases GI motility |
