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6 Cards in this Set
- Front
- Back
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What are the 3 methods PCN kill bacteria?
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1) PBPs in the periplasmic space bind the PCN - allows PCN to accumulate in bacteria.
2) PCN inhibits transpeptidases - interferes with "mesh" formation of cell wall - kills cell 3) PCH stims autolysins - PCN keeps autolysins active which damages the cell wall and lyses the bacteria |
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What are the different types of PCN?
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1st gen - Narrow spectrum (beta lactamase sensitive) - Pen G/V
2nd gen - beta-lactmase resistant - Methicillin, Dicloxacillin, Oxacillin, Cloxacillin, Nafcillin, Flucloxacillin - good for bacteria that have resistance from beta lactams. 3rd gen - Broad spectrum - Ampicillin (Listeria), Amoxicillin (dental prophylaxis) - good for G +/- 4th gen - extended spectrum - Carbenicillin, piperacillin, ticarcillin - antipseudomonal (pseudomonas aerudinosa) - always use in combo with aminoglycoside or cipro |
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What do the cephalosporin generations treat?
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1st - Proteus, E. Coli, Klebsiella (PLUS G+) - PECK
2nd - H. influenzae, Enterobacter aerogenes, Neisseria, plus PECK (HENPECK) 3rd - HENPECK (plus enterics) |
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What are the 2nd gen cephalosporins?
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cefaMANdole - disulfiram reaction
ceFOXitin - PID and intra ab infections ceFURoxime - cross BBB cefoTETan |
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What are the 3rd gen cephalosporins?
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Tough Assassins
cefTAzidime - P. Aeruginosa cefoTAxime cefTriAxone - excreted in bile - DOC for N. Gonorrhea |
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What are the 4th gen cephalosporins?
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Pseudomonas Insults
cefePIme cefPIrome |
